Roadblock: improved annotations do not necessarily translate into new functional insights

Nicola A L Hall^{1

2}, Becky C Carlyle³, Wilfried Haerty^{4

5}, Elizabeth M Tunbridge^{6

7}

Affiliations

¹ Department of Psychiatry, University of Oxford, Oxford, UK. nicola.hall@psych.ox.ac.uk.
² Oxford Health NHS Foundation Trust, Oxford, UK. nicola.hall@psych.ox.ac.uk.
³ Massachusetts General Hospital, Boston, USA.
⁴ The Earlham Institute, Norwich, UK.
⁵ School of Biological Sciences, University of East Anglia, Norwich, UK.
⁶ Department of Psychiatry, University of Oxford, Oxford, UK.
⁷ Oxford Health NHS Foundation Trust, Oxford, UK.

Editorial

Nicola A L Hall et al. Genome Biol. 2021.

. 2021 Nov 22;22(1):320.

doi: 10.1186/s13059-021-02542-5.

Nicola A L Hall^{1

2}, Becky C Carlyle³, Wilfried Haerty^{4

5}, Elizabeth M Tunbridge^{6

7}

¹ Department of Psychiatry, University of Oxford, Oxford, UK. nicola.hall@psych.ox.ac.uk.
² Oxford Health NHS Foundation Trust, Oxford, UK. nicola.hall@psych.ox.ac.uk.
³ Massachusetts General Hospital, Boston, USA.
⁴ The Earlham Institute, Norwich, UK.
⁵ School of Biological Sciences, University of East Anglia, Norwich, UK.
⁶ Department of Psychiatry, University of Oxford, Oxford, UK.
⁷ Oxford Health NHS Foundation Trust, Oxford, UK.

No abstract available

Conflict of interest statement

The authors declare that they have no competing interests.

1. Pertea M, Shumate A, Pertea G, Varabyou A, Breitwieser FP, Chang Y-C, et al. CHESS: a new human gene catalog curated from thousands of large-scale RNA sequencing experiments reveals extensive transcriptional noise. Genome Biology. 2018;19(1):208. doi: 10.1186/s13059-018-1590-2. - DOI - PMC - PubMed
1. Steijger T, Abril JF, Engström PG, Kokocinski F, Abril JF, Akerman M, et al. Assessment of transcript reconstruction methods for RNA-seq. Nature Methods. 2013;10(12):1177–1184. doi: 10.1038/nmeth.2714. - DOI - PMC - PubMed
1. Conesa A, Madrigal P, Tarazona S, Gomez-Cabrero D, Cervera A, McPherson A, et al. A survey of best practices for RNA-seq data analysis. Genome Biology. 2016;17(1):13. doi: 10.1186/s13059-016-0881-8. - DOI - PMC - PubMed
1. van Dijk EL, Jaszczyszyn Y, Thermes C. Library preparation methods for next-generation sequencing: tone down the bias. Experimental Cell Research. 2014;322(1):12–20. doi: 10.1016/j.yexcr.2014.01.008. - DOI - PubMed
1. Jaffe AE, Hoeppner DJ, Saito T, Blanpain L, Ukaigwe J, Burke EE, et al. Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk. Nature Neuroscience. 2020;23(4):510–519. doi: 10.1038/s41593-020-0604-z. - DOI - PubMed