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Observational Study
. 2021 Nov 22;11(1):22680.
doi: 10.1038/s41598-021-01941-9.

Mycoplasma infection and ocular surface diseases: a nationwide cohort study

Li-Ju Lai #  1 , Vincent Chin-Hung Chen #  2   3 , Yao-Hsu Yang  4   5   6 , Kai-Liang Kao  7 , Ko-Jung Chen  6 , Ying-Ching Wang  8 , Shu-I Wu  9   10
Affiliations
Observational Study

Mycoplasma infection and ocular surface diseases: a nationwide cohort study

Li-Ju Lai et al. Sci Rep. .

Abstract

Whether patients with Mycoplasma infection have an increased risk of ocular surface ulcers. Using a nation-wide database, we identified patients with a new diagnosis of Mycoplasma infection between 1997 and 2013, and compared them with age-, sex-, and index year-matched subjects without the infection. Cox proportional regression was performed to compare the risk of corneal diseases between the two cohorts. The incidence of corneal diseases was significantly higher in the 4223 patients with Mycoplasma infection than in the 16,892 patients without (7.28 vs. 5.94 per 1000 person-years, P < 0.01). The adjusted hazard ratio for the risk of corneal diseases in the study cohort was 1.21 times higher (95% CI 1.02-1.44) than that in the comparison cohort. Mycoplasma infection might be a predisposing factor for patients with keratitis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Cumulative incidence of corneal infection in patients with and without Mycoplasma pneumonia infection.
See this image and copyright information in PMC

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References

    1. Lakhundi S, Siddiqui R, Khan NA. Pathogenesis of microbial keratitis. Microb. Pathog. 2017;104:97–109. doi: 10.1016/j.micpath.2016.12.013. - DOI - PubMed
    1. Wilhelmus HK, Liesegang TG, Osato MS, Jones DB. Cumitech 13A: Laboratory Diagnosis of Ocular Infections. American Society of Microbiology; 1994. pp. 157–168.
    1. Chidambaram JD, Prajna NV, Larke NL, et al. Prospective study of the diagnostic accuracy of the in vivo laser scanning confocal microscope for severe microbial keratitis. Ophthalmology. 2016;123:2285–2293. doi: 10.1016/j.ophtha.2016.07.009. - DOI - PMC - PubMed
    1. Ranjini CY, Waddepally VV. Microbial profile of corneal ulcers in a tertiary care hospital in south India. J. Ophthalmic Vis. Res. 2016;11:363–367. doi: 10.4103/2008-322X.194071. - DOI - PMC - PubMed
    1. Suwal S, Bhandari D, Thapa P, Shrestha MK, Amatya J. Microbiological profile of corneal ulcer cases diagnosed in a tertiary care ophthalmological institute in Nepal. BMC Ophthalmol. 2016;16:209. doi: 10.1186/s12886-016-0388-9. - DOI - PMC - PubMed

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