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Review
. 2021 Nov 13:2021:9011226.
doi: 10.1155/2021/9011226. eCollection 2021.

Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity

Lotfollah Kamali Hakim  1   2   3 , Mohsen Yazdanian  1 , Mostafa Alam  4 , Kamyar Abbasi  5 , Hamid Tebyaniyan  6 , Elahe Tahmasebi  1 , Danial Khayatan  7 , Alexander Seifalian  8 , Reza Ranjbar  1   2 , Alireza Yazdanian  9
Affiliations
Review

Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity

Lotfollah Kamali Hakim et al. Evid Based Complement Alternat Med. .

Abstract

Biomaterials applications have rapidly expanded into different fields of sciences. One of the important fields of using biomaterials is dentistry, which can facilitate implantation, surgery, and treatment of oral diseases such as peri-implantitis, periodontitis, and other dental problems. Drug delivery systems based on biocompatible materials play a vital role in the release of drugs into aim tissues of the oral cavity with minimum side effects. Therefore, scientists have studied various delivery systems to improve the efficacy and acceptability of therapeutic approaches in dental problems and oral diseases. Also, biomaterials could be utilized as carriers in biocompatible drug delivery systems. For instance, natural polymeric substances, such as gelatin, chitosan, calcium phosphate, alginate, and xanthan gum are used to prepare different forms of delivery systems. In addition, some alloys are conducted in drug complexes for the better in transportation. Delivery systems based on biomaterials are provided with different strategies, although individual biomaterial has advantages and disadvantages which have a significant influence on transportation of complex such as solubility in physiological environments or distribution in tissues. Biomaterials have antibacterial and anti-inflammatory effects and prolonged time contact and even enhance antibiotic activities in oral infections. Moreover, these biomaterials are commonly prepared in some forms such as particulate complex, fibers, microspheres, gels, hydrogels, and injectable systems. In this review, we examined the application of biocompatible materials in drug delivery systems of oral and dental diseases or problems.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Some of the most important properties that can be enhanced in dentistry [12].
Figure 2
Figure 2
Chitosan-based particulate formulations following various strategies [40].
Figure 3
Figure 3
Chitosan induces a transgenic response and delivers nucleic acids intracellularly [40].
See this image and copyright information in PMC

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