Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;98(1):272-274.
doi: 10.1111/php.13565. Epub 2021 Dec 1.

Substituent Effect in Pyridinium Alkynylanthracenes on their Performance as Photosensitizers for Photodynamic Therapy

Valentina Brega  1 , Samuel W Thomas 3rd  1
Affiliations

Substituent Effect in Pyridinium Alkynylanthracenes on their Performance as Photosensitizers for Photodynamic Therapy

Valentina Brega et al. Photochem Photobiol. 2022 Jan.

Abstract

Progress in photodynamic therapy (PDT) relies on the design and synthesis of photosensitizers that can efficiently sensitize singlet oxygen using visible light irradiation while displaying limited dark toxicity. Here, we highlight the paper by Linker and coworkers published in this issue of Photochemistry and Photobiology, which evaluates the effect of the regiochemistry of pyridinium rings in three isomeric pyridinium alkynylanthracenes on their performance as photosensitizers for PDT in HeLa cells.

PubMed Disclaimer

References

REFERENCES

    1. Dolmans, D. E. J. G. J., D. Fukumura and R. K. Jain (2003) Photodynamic therapy for cancer. Nat. Rev. Cancer 3, 380-387.
    1. Zhang, J., Z. C. Smith and S. W. Thomas (2014) Electronic effects of ring fusion and alkyne substitution on acene properties and reactivity. J. Organic Chem. 79, 10081-10093.
    1. Anthony, J. E. (2006) Functionalized acenes and heteroacenes for organic electronics. Chem. Rev. 106, 5028-5048.
    1. Anthony, J. E. (2008) The larger acenes: versatile organic semiconductors. Angew. Chem. Int. Ed. 47, 452-483.
    1. Zhang, J., R. H. Pawle, T. E. Haas and S. W. Thomas (2014) Combining electronic and steric effects for highly stable unsymmetric pentacenes. Chem. Eur. J. 20, 5880-5884.

LinkOut - more resources