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Case Reports
. 2022 Mar;104(3):e79-e80.
doi: 10.1308/rcsann.2021.0116. Epub 2021 Nov 23.

Kikuchi-Fujimoto disease: a rare cause of histiocytic necrotising lymphadenitis in young ethnic women

J P Ramchandani  1 , A Gupta  1 , M Goh  2 , A Dalal  2
Affiliations
Case Reports

Kikuchi-Fujimoto disease: a rare cause of histiocytic necrotising lymphadenitis in young ethnic women

J P Ramchandani et al. Ann R Coll Surg Engl. 2022 Mar.

Abstract

Kikuchi-Fujimoto is a rare but self-limiting disease usually affecting young ethnic females. The main clinical presentation is fever and cervical lymphadenopathy. Here we describe the cases of two patients with cervical lymphadenopathy, fever and fatigue. In addition, patients can present with neutropenia; hence, early diagnosis is crucial to exclude a malignant cause.

Keywords: Cervical lymphadenopathy; Kikuchi–Fujimoto disease; Necrotising lymphadenitis.

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Figures

Figure 1
Figure 1
Histology showing abundant histiocytes and necrosis
See this image and copyright information in PMC

References

    1. Lahma J, Arkoubi Z, Hejjouji Ret al. . About a rare disease misdiagnosed as malignant lymphoma or tuberculosis: Kikuchi–Fujimoto’s disease. Pan Afr Med J 2018; 31: 77.10.11604/pamj.2018.31.77.16569 - DOI - PMC - PubMed
    1. Fujimoto Y, Kojima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis: a new clinicopathological entity. Nippon Naika Gakkai Zasshi 1972; 20: 920–927.
    1. Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis. Nippon Ketsueki Gakkai Zasshi 1972; 35: 379–380.
    1. Perry AM, Choi SM. Kikuchi–Fujimoto disease: a review. Arch Pathol Lab Med 2018; 142: 1341–1346.10.5858/arpa.2018-0219-RA - DOI - PubMed
    1. Xu S, Sun W, Liu J. Kikuchi–Fujimoto disease: a case report and the evaluation of diagnostic procedures. BMC Oral Health 2019; 19: 223.10.1186/s12903-019-0920-4 - DOI - PMC - PubMed

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