Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Nov 16;9(11):e05086.
doi: 10.1002/ccr3.5086. eCollection 2021 Nov.

Patient and caregiver perspectives on transitioning to oral prophylaxis in the emerging hereditary angioedema treatment landscape

Affiliations
Case Reports

Patient and caregiver perspectives on transitioning to oral prophylaxis in the emerging hereditary angioedema treatment landscape

Daniel F Soteres et al. Clin Case Rep. .

Abstract

This report describes the successful transition of two familial patients with HAE from injectable to oral prophylaxis without tapering prior therapy or employing a complex transition protocol.

Keywords: Haegarda; berotralstat; hereditary angioedema; shared decision‐making; switching; treatment burden.

PubMed Disclaimer

Conflict of interest statement

Daniel F. Soteres, MD, MPH, is a clinical research investigator for Takeda and BioCryst and has accepted speaker or advisory board fees from Takeda, BioCryst, CSL Behring, and Pharming. Fellicia Grimes, BS, has no conflicts of interest to declare.

References

    1. Busse PJ, Christiansen SC, Riedl MA, et al. US HAEA Medical Advisory Board 2020 guidelines for the management of hereditary angioedema. J Allergy Clin Immunol Pract. 2021;9(1):132‐150. - PubMed
    1. Lumry WR, Settipane RA. Hereditary angioedema: epidemiology and burden of disease. Allergy Asthma Proc. 2020;41(6):S08‐S13. - PubMed
    1. Banday AZ, Kaur A, Jindal AK, Rawat A, Singh S. An update on the genetics and pathogenesis of hereditary angioedema. Genes Dis. 2020;7(1):75‐83. - PMC - PubMed
    1. Longhurst HJ, Bork K. Hereditary angioedema: an update on causes, manifestations and treatment. Br J Hosp Med (Lond). 2019;80(7):391‐398. - PubMed
    1. CINRYZE (C1 esterase inhibitor [human]) for intravenous use, freeze‐dried powder for reconstitution [prescribing information]. 2018. Lexington, MA: Shire ViroPharma Incorporated.

Publication types

LinkOut - more resources