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. 2022 May;31(5):821-822.
doi: 10.1111/exd.14505. Epub 2021 Dec 2.

Ketoconazole beyond antifungal activity: Bioinformatics-based hypothesis on lipid metabolism in dandruff and seborrheic dermatitis

Vinicius Goularte-Silva  1 , Luciana Campos Paulino  1
Affiliations

Ketoconazole beyond antifungal activity: Bioinformatics-based hypothesis on lipid metabolism in dandruff and seborrheic dermatitis

Vinicius Goularte-Silva et al. Exp Dermatol. 2022 May.

Abstract

The role of Malassezia yeasts in dandruff and seborrheic dermatitis is unclear; however, antifungal therapy with ketoconazole is commonly used. We propose that ketoconazole shifts skin lipid profile, affects Malassezia lipid metabolism and favours biotin-producing bacteria. Biotin regulates inflammatory response and cell proliferation, contributing to symptom improvement.

Keywords: Malassezia; biotin; lipid metabolism; microbiota; skin.

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References

REFERENCES

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