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. 2021 Nov 19:76:e3501.
doi: 10.6061/clinics/2021/e3501. eCollection 2021.

Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine

Alberto C Helito  1 , Livia Lindoso  1 , Sofia M Sieczkowska  1 , Camilla Astley  1 , Ligia B Queiroz  1 , Natalia Rose  1 , Claudia Renata P Santos  1 , Thalis Bolzan  1 , Rita María I A Peralta  1 , Ruth R Franco  1 , Louise Cominato  1 , Rosa Maria R Pereira  1 , Uenis Tannuri  1 , Lucia Maria A Campos  1 , Benito Lourenço  1 , Ricardo K Toma  1 , Karina Medeiros  1 , Andréia Watanabe  1 , Patricia Moreno Grangeiro  1 , Sylvia C Farhat  1 , Caio B Casella  1 , Guilherme V Polanczyk  1 , Bruno Gualano  1 , Clovis A Silva  1 ; HC-FMUSP Adolescent COVID-19 Study Group; Adriana M E Sallum  2 , Amanda Y Iraha  2 , Bianca P Ihara  2 , Bruna C Mazzolani  2 , Claudia A Martinez  2 , Claudia A A Strabelli  2 , Claudia B Fonseca  2 , Dandara C C Lima  2 , Debora N D Setoue  2 , Deborah F P Roz  2 , Fabiana I Smaira  2 , Hamilton Roschel  2 , Helena T Miyatani  2 , Isabela G Marques  2 , Jane Oba  2 , Juliana C O Ferreira  2 , Juliana R Simon  2 , Katia Kozu  2 , Ligia P Saccani  2 , Lorena V M Martiniano  2 , Luana C A Miranda  2 , Luiz E V Silva  2 , Moisés F Laurentino  2 , Nadia E Aikawa  2 , Neusa K Sakita  2 , Nicolas Y Tanigava  2 , Paulo R A Pereira  2 , Patrícia Palmeira  2 , Simone S Angelo  2 , Sofia S M Lavorato  2 , Tamires M Bernardes  2 , Tathiane C Franco  2 , Vivianne S L Viana  2 , Vera P M F R Barros  2 , Yingying Zheng  2
Affiliations

Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine

Alberto C Helito et al. Clinics (Sao Paulo). .

Abstract

Objective: To assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during the coronavirus disease 2019 (COVID-19) pandemic.

Methods: This cross-sectional study included 305 adolescents with chronic immunocompromised conditions and 82 healthy adolescents. Online surveys were completed, which included questions on socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and the following validated questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), and Pediatric Outcome Data Collection Instrument (PODCI).

Results: The median current age [14 (10-18) vs. 15 (10-18) years, p=0.847] and frequency of female sex (62% vs. 58%, p=0.571) were similar in adolescents with chronic conditions compared with healthy adolescents. The frequency of poor sleep quality was similar in both groups (38% vs. 48%, p=0.118). Logistic regression analysis, including both healthy adolescents and adolescents with chronic conditions (n=387), demonstrated that self-reported increase in screen time (odds ratio [OR] 3.0; 95% confidence interval [CI] 1.3-6.8; p=0.008) and intrafamilial violence report (OR 2.1; 95% CI 1.2-3.5; p=0.008) were independently associated with poor sleep quality in these adolescents. However, the PODCI global function score was associated with a lower OR for poor sleep quality (OR 0.97; 95% CI 0.94-0.99; p=0.001). Further logistic regression, including only adolescents with chronic conditions (n=305), demonstrated that self-reported increase in screen time (OR 3.1; 95% CI 1.4-6.8; p=0.006) and intrafamilial violence report (OR 2.0; 95% CI 1.2-3.4; p=0.011) remained independently associated with poor quality of sleep, whereas a lower PODCI global function score was associated with a lower OR for sleep quality (OR 0.96; 95% CI 0.94-0.98; p<0.001).

Conclusion: Self-reported increases in screen time and intrafamilial violence report impacted sleep quality in both healthy adolescents and those with chronic conditions. Decreased health-related quality of life was observed in adolescents with poor sleep quality.

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Conflict of interest statement

No potential conflict of interest was reported.

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