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. 2021 Nov 1;4(11):e2136030.
doi: 10.1001/jamanetworkopen.2021.36030.

Assessment of 4 Doses of SARS-CoV-2 Messenger RNA-Based Vaccine in Recipients of a Solid Organ Transplant

Nassim Kamar  1   2   3 , Florence Abravanel  2   3   4 , Olivier Marion  1   2   3 , Raphaelle Romieu-Mourez  4 , Chloé Couat  1 , Arnaud Del Bello  1   3 , Jacques Izopet  2   3   4
Affiliations

Assessment of 4 Doses of SARS-CoV-2 Messenger RNA-Based Vaccine in Recipients of a Solid Organ Transplant

Nassim Kamar et al. JAMA Netw Open. .

Abstract

This case series study assesses whether a fourth dose of a SARS-CoV-2 messenger RNA (mRNA)–based vaccine is associated with improved anti–SARS-CoV-2 antibody response in solid organ transplant recipients in France.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Kamar reported receiving speaker fees and participating in advisory boards for AbbVie, Astellas, Biotest, CSL Behring, Chiesi, Merck Sharp and Dohme, Neovii, Novartis Pharma, Sanofi, Sandoz, Shire, and Takeda and receiving personal fees from AbbVie, Astellas, Biotest, CSL Behring, Chiesi, Merck Sharp and Dohme, Neovii, Novartis Pharma, Sanofi, Sandoz, Shire, and Takeda outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Anti–SARS-CoV-2 Antibody Concentrations and Number of SARS-CoV-2–Reactive IFN-γ–Producing Cells After a Fourth Dose of the SARS-CoV-2 Messenger RNA (mRNA) BNT162b2 Vaccine
A, The dotted line represents the cutoff value. B, The numbers of cells reactive to overlapping peptide pools spanning SARS-CoV-2 structural protein S (pools S1 and S2) are shown. The numbers of SARS-CoV-2–reactive IFN-γ–producing cells in the 3 patients who had a low antibody concentration before the fourth dose were 17.5, 47.5, and 110 spot-forming units (SFUs) per 106 peripheral blood mononuclear cells (PBMCs). BAU indicates binding antibody unit.
See this image and copyright information in PMC

References

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