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. 2022 Feb;240(2):537-548.
doi: 10.1007/s00221-021-06266-7. Epub 2021 Nov 24.

Human mirror neuron system responsivity to unimodal and multimodal presentations of action

Fran Copelli  1 , Joseph Rovetti  1 , Paolo Ammirante  1 , Frank A Russo  2
Affiliations

Human mirror neuron system responsivity to unimodal and multimodal presentations of action

Fran Copelli et al. Exp Brain Res. 2022 Feb.

Abstract

This study aims to clarify unresolved questions from two earlier studies by McGarry et al. Exp Brain Res 218(4): 527-538, 2012 and Kaplan and Iacoboni Cogn Process 8: 103-113, 2007 on human mirror neuron system (hMNS) responsivity to multimodal presentations of actions. These questions are: (1) whether the two frontal areas originally identified by Kaplan and Iacoboni (ventral premotor cortex [vPMC] and inferior frontal gyrus [IFG]) are both part of the hMNS (i.e., do they respond to execution as well as observation), (2) whether both areas yield effects of biologicalness (biological, control) and modality (audio, visual, audiovisual), and (3) whether the vPMC is preferentially responsive to multimodal input. To resolve these questions about the hMNS, we replicated and extended McGarry et al.'s electroencephalography (EEG) study, while incorporating advanced source localization methods. Participants were asked to execute movements (ripping paper) as well as observe those movements across the same three modalities (audio, visual, and audiovisual), all while 64-channel EEG data was recorded. Two frontal sources consistent with those identified in prior studies showed mu event-related desynchronization (mu-ERD) under execution and observation conditions. These sources also showed a greater response to biological movement than to control stimuli as well as a distinct visual advantage, with greater responsivity to visual and audiovisual compared to audio conditions. Exploratory analyses of mu-ERD in the vPMC under visual and audiovisual observation conditions suggests that the hMNS tracks the magnitude of visual movement over time.

Keywords: Biological movement; EEG; Independent component analysis; Mirror neuron system; Modality.

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