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. 2021 Nov 24;16(11):e0259979.
doi: 10.1371/journal.pone.0259979. eCollection 2021.

Pre hospital delay and its associated factors in acute myocardial infarction in a developing country

Ishmum Zia Chowdhury  1 , Md Nurul Amin  2 , Mashhud Zia Chowdhury  3 , Sharar Muhib Rahman  1 , Mohsin Ahmed  4 , F Aaysha Cader  3
Affiliations

Pre hospital delay and its associated factors in acute myocardial infarction in a developing country

Ishmum Zia Chowdhury et al. PLoS One. .

Abstract

Background: Early revascularization and treatment is key to improving clinical outcomes and reducing mortality in acute myocardial infarction (AMI). In low- and middle-income countries such as Bangladesh, timely management of AMI is challenging, with pre-hospital delays playing a significant role. This study was designed to investigate pre-hospital delay and its associated factors among patients presenting with AMI in the capital city of Dhaka.

Methods: This retrospective cohort study was conducted on 333 patients presenting with AMI over a 3-month period at two of the largest primary reperfusion-capable tertiary cardiac care centres in Dhaka. Of the total patients, 239(71.8%) were admitted in the National Institute of Cardiovascular Diseases, Dhaka and 94(28.2%) at Ibrahim Cardiac Hospital & Research Institute, Dhaka Data were collected from patients by semi-structured interview and hospital medical records. Pre-hospital delay (median and inter-quartile range) was calculated. Statistical significance was determined by Chi-square test. Multivariate logistic regression analysis was done to determine the independent predictors of pre-hospital delay.

Results: The mean age of the respondents was 53.8±11.2 years. Two-thirds (67.6%) of the respondents were males. Median total pre-hospital delay was 11.5 (IQR-18.3) hours with median decision time from symptom onset to seeking medical care being 3.0 (IQR: 11.0) hours. Nearly half (48.9%) of patients presented to the hospital more than 12 hours after symptom onset. On multivariate logistic regression analysis, AMI patients with absence of typical chest pain [OR 5.21; (95% CI: 2.5-9.9)], diabetes [OR: 1.7 (95% CI: 1.0-2.9)], residing/staying > 30 km away from nearest hospital at the time of onset [OR: 4.3(95% CI = 2.3-7.2)] and belonged to lower and middle class [OR: 1.9(95% CI = 1.0-3.5)] were significantly associated with pre-hospital delays.

Conclusion: Acute myocardial infarction (AMI) patients with atypical chest pain, diabetes, staying far away from nearest hospital and belonged to lower and middle socioeconomic strata were significantly associated with pre-hospital delays. The findings could have immense implications for improvements about timely reaching of AMI patients to the hospital within the context of their sociodemographic status and geographic barriers of the city.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Working definitions for time intervals related to pre-hospital delay.
Fig 2
Fig 2. Histogram showing distribution of decision time with right skewness.
Fig 3
Fig 3. Histogram showing distribution of time to NICVD/ICHRI with right skewness.
Fig 4
Fig 4. Histogram showing distribution of time to receive treatment with right skewness.
See this image and copyright information in PMC

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