Review

. 2021 Dec;6(12):1483-1492.

doi: 10.1038/s41564-021-00999-5. Epub 2021 Nov 24.

The science of the host-virus network

Gregory F Albery¹, Daniel J Becker², Liam Brierley³, Cara E Brook⁴, Rebecca C Christofferson⁵, Lily E Cohen⁶, Tad A Dallas⁷, Evan A Eskew⁸, Anna Fagre⁹, Maxwell J Farrell¹⁰, Emma Glennon¹¹, Sarah Guth⁴, Maxwell B Joseph¹², Nardus Mollentze^{13

14}, Benjamin A Neely¹⁵, Timothée Poisot^{16

17}, Angela L Rasmussen^{18

19}, Sadie J Ryan^{20

21

22}, Stephanie Seifert²³, Anna R Sjodin²⁴, Erin M Sorrell^{25

26}, Colin J Carlson^{27

28}

Affiliations

¹ Department of Biology, Georgetown University, Washington DC, USA. gfalbery@gmail.com.
² Department of Biology, University of Oklahoma, Norman, OK, USA.
³ Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
⁴ Department of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.
⁵ Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA, USA.
⁶ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁷ Department of Biological Sciences, University of South Carolina, Columbia, SC, USA.
⁸ Department of Biology, Pacific Lutheran University, Tacoma, WA, USA.
⁹ Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
¹⁰ Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.
¹¹ Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
¹² Earth Lab, Cooperative Institute for Research in Environmental Science, University of Colorado Boulder, Boulder, CO, USA.
¹³ Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
¹⁴ MRC - University of Glasgow Centre for Virus Research, Glasgow, UK.
¹⁵ National Institute of Standards and Technology, Charleston, SC, USA.
¹⁶ Québec Centre for Biodiversity Sciences, Montréal, Québec, Canada.
¹⁷ Département de Sciences Biologiques, Université de Montréal, Montréal, Québec, Canada.
¹⁸ Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
¹⁹ Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
²⁰ Department of Geography, University of Florida, Gainesville, FL, USA.
²¹ Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
²² School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.
²³ Paul G. Allen School for Global Health, Washington State University, Pullman, WA, USA.
²⁴ Department of Biological Sciences, University of Idaho, Moscow, ID, USA.
²⁵ Center for Global Health Science and Security, Georgetown University Medical Center, Washington, DC, USA.
²⁶ Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA.
²⁷ Center for Global Health Science and Security, Georgetown University Medical Center, Washington, DC, USA. colin.carlson@georgetown.edu.
²⁸ Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA. colin.carlson@georgetown.edu.

PMID: 34819645
DOI: 10.1038/s41564-021-00999-5

Free article

Review

The science of the host-virus network

Gregory F Albery et al. Nat Microbiol. 2021 Dec.

Free article

. 2021 Dec;6(12):1483-1492.

doi: 10.1038/s41564-021-00999-5. Epub 2021 Nov 24.

Authors

Affiliations

¹ Department of Biology, Georgetown University, Washington DC, USA. gfalbery@gmail.com.
² Department of Biology, University of Oklahoma, Norman, OK, USA.
³ Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
⁴ Department of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.
⁵ Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA, USA.
⁶ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁷ Department of Biological Sciences, University of South Carolina, Columbia, SC, USA.
⁸ Department of Biology, Pacific Lutheran University, Tacoma, WA, USA.
⁹ Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
¹⁰ Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.
¹¹ Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
¹² Earth Lab, Cooperative Institute for Research in Environmental Science, University of Colorado Boulder, Boulder, CO, USA.
¹³ Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
¹⁴ MRC - University of Glasgow Centre for Virus Research, Glasgow, UK.
¹⁵ National Institute of Standards and Technology, Charleston, SC, USA.
¹⁶ Québec Centre for Biodiversity Sciences, Montréal, Québec, Canada.
¹⁷ Département de Sciences Biologiques, Université de Montréal, Montréal, Québec, Canada.
¹⁸ Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
¹⁹ Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
²⁰ Department of Geography, University of Florida, Gainesville, FL, USA.
²¹ Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
²² School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.
²³ Paul G. Allen School for Global Health, Washington State University, Pullman, WA, USA.
²⁴ Department of Biological Sciences, University of Idaho, Moscow, ID, USA.
²⁵ Center for Global Health Science and Security, Georgetown University Medical Center, Washington, DC, USA.
²⁶ Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA.
²⁷ Center for Global Health Science and Security, Georgetown University Medical Center, Washington, DC, USA. colin.carlson@georgetown.edu.
²⁸ Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA. colin.carlson@georgetown.edu.

PMID: 34819645
DOI: 10.1038/s41564-021-00999-5

Abstract

Better methods to predict and prevent the emergence of zoonotic viruses could support future efforts to reduce the risk of epidemics. We propose a network science framework for understanding and predicting human and animal susceptibility to viral infections. Related approaches have so far helped to identify basic biological rules that govern cross-species transmission and structure the global virome. We highlight ways to make modelling both accurate and actionable, and discuss the barriers that prevent researchers from translating viral ecology into public health policies that could prevent future pandemics.

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The science of the host-virus network

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The science of the host-virus network

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