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Review
. 2021 Nov 8:9:662418.
doi: 10.3389/fbioe.2021.662418. eCollection 2021.

Tissue Engineering in Stomatology: A Review of Potential Approaches for Oral Disease Treatments

Lilan Cao  1 , Huiying Su  1 , Mengying Si  1 , Jing Xu  1 , Xin Chang  1 , Jiajia Lv  1   2 , Yuankun Zhai  1   2
Affiliations
Review

Tissue Engineering in Stomatology: A Review of Potential Approaches for Oral Disease Treatments

Lilan Cao et al. Front Bioeng Biotechnol. .

Abstract

Tissue engineering is an emerging discipline that combines engineering and life sciences. It can construct functional biological structures in vivo or in vitro to replace native tissues or organs and minimize serious shortages of donor organs during tissue and organ reconstruction or transplantation. Organ transplantation has achieved success by using the tissue-engineered heart, liver, kidney, and other artificial organs, and the emergence of tissue-engineered bone also provides a new approach for the healing of human bone defects. In recent years, tissue engineering technology has gradually become an important technical method for dentistry research, and its application in stomatology-related research has also obtained impressive achievements. The purpose of this review is to summarize the research advances of tissue engineering and its application in stomatology. These aspects include tooth, periodontal, dental implant, cleft palate, oral and maxillofacial skin or mucosa, and oral and maxillofacial bone tissue engineering. In addition, this article also summarizes the commonly used cells, scaffolds, and growth factors in stomatology and discusses the limitations of tissue engineering in stomatology from the perspective of cells, scaffolds, and clinical applications.

Keywords: cleft palate; dental implants; growth factors; oral and maxillofacial bone; oral and maxillofacial skin or mucosa; periodontal; scaffolds; tissue engineering.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Application of tissue engineering. At present, tissue engineering has been widely used in many fields, including the heart, liver, kidney, spleen, bone, and teeth.
FIGURE 2
FIGURE 2
Principles of tissue engineering. Various cells extracted from the oral cavity are seeded on scaffolds adsorbed with growth factors, and the required tissues or organs can be obtained after appropriate in vitro culture and then implanted in vivo.
FIGURE 3
FIGURE 3
Procedure of dental implant. First, prepare the implant socket on alveolar bone; second, place the implant into socket; then install the abutment; finally, install the artificial crown.
See this image and copyright information in PMC

References

    1. Adhikari J., Roy A., Das A., Ghosh M., Thomas S., Sinha A., et al. (2021). Effects of Processing Parameters of 3D Bioprinting on the Cellular Activity of Bioinks. Macromol. Biosci. 21 (1), 2000179. 10.1002/mabi.202000179 - DOI - PubMed
    1. Adib M., Alipour R., Hashemi-Beni B., Sadeghi F. (2014). The Effect of Stem Cell from Human Exfoliated Deciduous Teeth on T Lymphocyte Proliferation. Adv. Biomed. Res. 3, 202. 10.4103/2277-9175.142312 - DOI - PMC - PubMed
    1. Aghamohamadi Z., Kadkhodazadeh M., Torshabi M., Tabatabaei F. (2020). A Compound of Concentrated Growth Factor and Periodontal Ligament Stem Cell-Derived Conditioned Medium. Tissue and Cell 65, 101373. 10.1016/j.tice.2020.101373 - DOI - PubMed
    1. Agrawal V., Sinha M. (2017). A Review on Carrier Systems for Bone Morphogenetic Protein-2. J. Biomed. Mater. Res. 105 (4), 904–925. 10.1002/jbm.b.33599 - DOI - PubMed
    1. Alkaisi A., Ismail A. R., Mutum S. S., Rifin Ahmad Z. A., Masudi S. a., Razak N. H. A. (2013). Transplantation of Human Dental Pulp Stem Cells: Enhance Bone Consolidation in Mandibular Distraction Osteogenesis. J. Oral Maxillofacial Surg. 71 (10), e1–1758. 10.1016/j.joms.2013.05.0161713 - DOI - PubMed

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