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. 2021 Nov 8:8:721845.
doi: 10.3389/fvets.2021.721845. eCollection 2021.

Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog

Fabiola de Oliveira Paes-Leme  1 , Eliana M Souza  1 , Paulo Ricardo Oliveira Paes  1 , Maderleine Geisa Gomes  1 , Felipe Santos Muniz  1 , Marco Túlio Gomes Campos  1 , Renata Barbosa Peixoto  1 , Patricia Donado Vaz de Melo  2 , Marcio H L Arndt  3 , Adriane Costa Val  1
Affiliations

Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog

Fabiola de Oliveira Paes-Leme et al. Front Vet Sci. .

Abstract

Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients' dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs.

Keywords: creatinine; cystatin C; dogs; failure; illness; insufficiency; kidney.

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Conflict of interest statement

PV was employed by company Labtest Diagnóstica S.A. MA was employed by company Enzytec, Biotecnologia Ltda. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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