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Observational Study
. 2022 Mar;24(3):564-569.
doi: 10.1111/dom.14607. Epub 2021 Dec 27.

Continuous glucose monitoring use and glucose variability in very young children with type 1 diabetes (VibRate): A multinational prospective observational real-world cohort study

Klemen Dovc  1   2 , Michelle Van Name  3 , Barbara Jenko Bizjan  1   2 , Ewa Rusak  4 , Claudia Piona  5 , Gul Yesiltepe-Mutlu  6   7 , Rosaline Mentink  8   9 , Giulio Frontino  10 , Maddalena Macedoni  11 , Sofia Helena Ferreira  12 , Joana Serra-Caetano  13 , Júlia Galhardo  14 , Julie Pelicand  15   16 , Francesca Silvestri  17 , Jennifer Sherr  3 , Agata Chobot  18   19 , Torben Biester  20 ; ISPAD JENIOUS Group
Affiliations
Observational Study

Continuous glucose monitoring use and glucose variability in very young children with type 1 diabetes (VibRate): A multinational prospective observational real-world cohort study

Klemen Dovc et al. Diabetes Obes Metab. 2022 Mar.
No abstract available

Keywords: children; continuous glucose monitoring; insulin pump; toddlers; type 1 diabetes.

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Conflict of interest statement

KD received honoraria for participation on the speakerʼs bureau of Pfizer, Novo Nordisk, and Eli Lilly. JG received speakerʼs honoraria from Eli Lilly and Sanofi, and clinical trials investigatorʼs payment from Novo Nordisk. RM received advisory board honoraria from Abbott and Novo Nordisk. JP received speakerʼs honoraria from Medtronic. JS serves as a consultant to Cecelia Health, Lexicon, Lilly, Insulet, Medtronic, and Sanofi, is a member of the advisory board for Bigfoot Biomedical, Cecelia Health, Insulet, Medtronic, and the T1D Fund and Vertex, and has had research support from the NIH, JDRF, and the Helmsley Charitable Trust. Her institution has had research support from Medtronic and Insulet. AC received speakerʼs honoraria from Medtronic, Eli Lilly, and Novo Nordisk. TB received speakerʼs honoraria from DexCom, Medtronic, Novo Nordisk, Roche, Sanofi, and Ypsomed, and advisory board honoraria from Ascensia, AstraZeneca, DexCom, Medtronic, and Sanofi.

No other potential conflicts of interest relevant to this study were reported.

Figures

FIGURE 1
FIGURE 1
A, Time in ranges, and B, Ambulatory glucose profile for children with type 1 diabetes using continuous glucose monitoring (CGM) or blood glucose monitoring (BGM) only. (A) Proportions of time below (<70 mg/dl [3.9 mmol/L]: red), in range (70‐180 mg/dl [3.9‐10 mmol/L]: green), and above (>180 mg/dl: yellow and orange; >250 mg/dl: orange) glucose range for the CGM and BGM‐only cohorts. Estimated differences. (B) Median (solid lines) and interquartile range (IQR; shaded regions) of CGM and BGM‐only glucose concentrations over the 24‐hour period. Dashed horizontal lines indicate the target glucose range (70 and 180 mg/dl [3.9 and 10 mmol/L]). Non‐parametric analyses for data on glucose control (paired non‐parametric Wilcoxon signed‐rank test) and outcome data are presented as median (IQR), although variables for the analyses utilized mean (glucose concentration, glucose concentration SD). *Estimated differences and P values were derived from a generalized linear mixed model, taking glucose monitoring modality as fixed effect, gender, age at visit, body mass index, number of glucose measurements, and minority status as covariates and centre as random effect. CV, coefficient of variation
See this image and copyright information in PMC

References

    1. Dovc K, Boughton C, Tauschmann M, et al. Young children have higher variability of insulin requirements: observations during hybrid closed‐loop insulin delivery. Diabetes Care. 2019;42(7):1344‐1347. - PMC - PubMed
    1. Omladič JŠ, Ozimič AS, Vovk A, et al. Acute hyperglycemia and spatial working memory in adolescents with type 1 diabetes. Diabetes Care. 2020;43(8):1941‐1944. - PMC - PubMed
    1. Mauras N, Buckingham B, White NH, et al. Impact of type 1 diabetes in the developing brain in children: a longitudinal study. Diabetes Care. 2021;44(4):983‐992. - PMC - PubMed
    1. Wilmot EG, Choudhary P, Leelarathna L, Baxter M. Glycaemic variability: the under‐recognized therapeutic target in type 1 diabetes care. Diabetes Obes Metab. 2019;21(12):2599‐2608. - PMC - PubMed
    1. Dimeglio LA, Acerini CL, Codner E, et al. Glycemic control targets and glucose monitoring for children, adolescents, and young adults with diabetes 2018 ISPAD Clinical Practice Consensus Guidelines. 2018;19(suppl 27):105‐114. - PubMed