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. 2021 Nov 15;11(11):457.
doi: 10.3390/bios11110457.

Real-World Outcomes of Glucose Sensor Use in Type 1 Diabetes-Findings from a Large UK Centre

Kyuhan Lee  1 , Shakthi Gunasinghe  1 , Alyson Chapman  2 , Lynne A Findlow  2 , Jody Hyland  2 , Sheetal Ohol  2 , Andrea Urwin  2 , Martin K Rutter  2   3 , Jonathan Schofield  2   3 , Hood Thabit  2   3 , Lalantha Leelarathna  2   3
Affiliations

Real-World Outcomes of Glucose Sensor Use in Type 1 Diabetes-Findings from a Large UK Centre

Kyuhan Lee et al. Biosensors (Basel). .

Abstract

Flash glucose monitoring (FGM) and real-time continuous glucose monitoring (RT-CGM) are increasingly used in clinical practice, with improvements in HbA1c and time in range (TIR) reported in clinical studies. We aimed to evaluate the impact of FGM and RT-CGM use on glycaemic outcomes in adults with type 1 diabetes (T1DM) under routine clinical care. We performed a retrospective data analysis from electronic outpatient records and proprietary web-based glucose monitoring platforms. We measured HbA1c (pre-sensor vs. on-sensor data) and sensor-based outcomes from the previous three months as per the international consensus on RT-CGM reporting guidelines. Amongst the 789 adults with T1DM, HbA1c level decreased from 61.0 (54.0, 71.0) mmol/mol to 57 (49, 65.8) mmol/mol in 561 people using FGM, and from 60.0 (50.0, 70.0) mmol/mol to 58.8 (50.3, 66.8) mmol/mol in 198 using RT-CGM (p < 0.001 for both). We found that 23% of FGM users and 32% of RT-CGM users achieved a time-in-range (TIR) (3.9 to 10 mmol/L) of >70%. For time-below-range (TBR) < 4 mmol/L, 70% of RT-CGM users and 58% of FGM users met international recommendations of <4%. Our data add to the growing body of evidence supporting the use of FGM and RT-CGM in T1DM.

Keywords: Dexcom G6; Freestyle Libre; continuous glucose monitoring; flash glucose monitoring; type 1 diabetes.

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Conflict of interest statement

K.L., S.G., A.C., L.A.F., J.H., S.O., A.U., M.K.R. and J.S. reports no relevant conflict of interest. L.L. has received personal fees from Abbott Diabetes Care and Dexcom Inc and research support from Dexcom Inc. H.T. has received research support from Dexcom Inc.

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