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. 2021 Dec 8;19(47):10385-10389.
doi: 10.1039/d1ob02086b.

Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions

Takashi Mino  1   2   3 , Yohei Fujisawa  1 , Shizuki Yoshida  1 , Mitsuru Hirama  1 , Takumu Akiyama  1 , Ryo Saito  1 , Yasushi Yoshida  1   2   3 , Yoshio Kasashima  4 , Masami Sakamoto  1   2
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Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions

Takashi Mino et al. Org Biomol Chem. .

Abstract

We synthesized cinnamoyl amide type chiral P,olefin ligand (S)-4. We successfully obtained separable diastereomers of 4d and demonstrated Pd-catalyzed asymmetric allylic substitution reactions of indoles using (S,aS)-4d as a chiral ligand with high enantioselectivities (up to 98% ee).

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