Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May;260(5):1509-1516.
doi: 10.1007/s00417-021-05502-8. Epub 2021 Nov 25.

Epiretinal proliferation after rhegmatogenous retinal detachment

Moritz Pettenkofer  1 , Ismael Chehaibou  2   3 , Cameron Pole  2   4 , Mercedes Rodriguez  2 , Gilad Rabina  2   5 , Allan E Kreiger  2 , Steven D Schwartz  2 , Jean-Pierre Hubschman  2
Affiliations

Epiretinal proliferation after rhegmatogenous retinal detachment

Moritz Pettenkofer et al. Graefes Arch Clin Exp Ophthalmol. 2022 May.

Erratum in

Abstract

Purpose: To determine the characteristics and appearance rate of epiretinal proliferation (ERP) on SD-OCT after surgery for rhegmatogenous retinal detachment (RRD) repair.

Methods: One hundred eight eyes of 108 patients who underwent one or more surgeries for RRD were enrolled. The eyes with other maculopathies that were directly related to RRD were excluded. Image acquisition was performed with SD-OCT (Heidelberg Engineering, Germany). Clinical charts were reviewed to assess clinical and surgical findings. Statistical analyses were performed using XLSTAT (Assinsoft, Paris, France).

Results: ERP was found in 9.3% eyes (n = 10). The mean initial visual acuity (logMAR) was 1.34 ± 0.82 in the ERP group compared to 0.49 ± 0.70 in the non-ERP group. PVR was present in 70.0% and chronic macular edema was found in 80.0% of eyes which developed ERP. The mean number of vitreoretinal surgeries in eyes with ERP was 3.3 ± 1.19 and only 1.44 ± 1.02 in eyes without. Silicone oil was used in 60.0% of eyes which developed ERP compared to 13.9% in the non-ERP group.

Conclusion: ERP is a late-onset postoperative finding in eyes with RRD and can occur in absence of macular holes. Overall, ERP is more frequent in eyes with complicated courses of RRD including multiple operations, PVR, usage of silicone oil, and chronic macular edema.

Keywords: Epiretinal membrane; Epiretinal proliferation; Macula; Müller cells; Postoperative complication; Proliferative vitreoretinopathy; Retina; Rhegmatogenous retinal detachment; Surgical retina; Vitrectomy.

PubMed Disclaimer

References

    1. Parolini B, Schumann RG, Cereda MG, Haritoglou C, Pertile G (2011) Lamellar macular hole: a clinicopathologic correlation of surgically excised epiretinal membranes. Invest Ophthalmol Vis Sci 52(12):9074–9083 - DOI
    1. Compera D, Entchev E, Haritoglou C, Scheler R, Mayer WJ, Wolf A, Kampik A, Schumann RG (2015) Lamellar hole-associated epiretinal proliferation in comparison to epiretinal membranes of macular pseudoholes. Am J Ophthalmol 160(2):373-384.e1 - DOI
    1. Pang CE, Maberley DA, Freund KB, White VA, Rasmussen S, To E, Matsubara JA (2016) Lamellar hole-associated epiretinal proliferation: a clinicopathologic correlation. Retina (Philadelphia, Pa) 36(7):1408–1412 - DOI
    1. Pang CE, Spaide RF, Freund KB (2014) Epiretinal proliferation seen in association with lamellar macular holes: a distinct clinical entity. Retina (Philadelphia, Pa) 34(8):1513–1523 - DOI
    1. Schumann RG, Hagenau F, Guenther SR, Wolf A, Priglinger SG, Vogt D (2019) Premacular cell proliferation profiles in tangential traction vitreo-maculopathies suggest a key role for hyalocytes. Ophthalmologica 242(2):106–112 - DOI

LinkOut - more resources