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. 2021 Nov 24;184(24):5851-5853.
doi: 10.1016/j.cell.2021.11.002.

The brain remembers where and how inflammation struck

Nadine Gogolla  1
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The brain remembers where and how inflammation struck

Nadine Gogolla. Cell. .

Abstract

Our immune system and brain interact on multiple scales, but how the brain represents and remembers immune challenges remains unclear. In this issue of Cell, Koren et al. (2021) reveal that the brain's insular cortex stores information about inflammation in the body. Strikingly, these immunological "memory engrams" can restore the initial disease state when reactivated.

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  • Insular cortex neurons encode and retrieve specific immune responses.
    Koren T, Yifa R, Amer M, Krot M, Boshnak N, Ben-Shaanan TL, Azulay-Debby H, Zalayat I, Avishai E, Hajjo H, Schiller M, Haykin H, Korin B, Farfara D, Hakim F, Kobiler O, Rosenblum K, Rolls A. Koren T, et al. Cell. 2021 Nov 24;184(24):5902-5915.e17. doi: 10.1016/j.cell.2021.10.013. Epub 2021 Nov 8. Cell. 2021. PMID: 34752731

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