Prediction value of plasma D-dimer level changes on venous thromboembolism during pregnancy

Abstract

Objective: To explore the changes in plasma D-dimer (D-D) levels of pregnant women during pregnancy and their predictive value for venous thromboembolism (VTE).

Methods: A selection of 240 pregnant women who came to our hospital for routine perinatal care and delivery from January 2018 to January 2019 were selected as the observation group, and 240 cases that came to our hospital for routine physical examination were served as the control group. The D-D levels of the two groups of women were compared, and the D-D levels of pregnant women in the observation group with different delivery methods were explored; the observation group was into VTE and non-VTE groups according to the occurrence of VTE, and the D-D levels of the two groups of pregnant women in different periods were compared, and its predictive value on VTE was analyzed.

Results: The observation group exhibited a notably higher D-D level than the control group (p < .001), and the D-D level of the observation group during the first trimester was lower than the second and third trimesters, with statistical difference observed (p < .001), and the second trimester was much lower than the third trimester (p < .001); the D-D level in pregnant women with vaginal delivery showed lower level when comparing with women with cesarean section (p < .001); the D-D level of the VTE group was remarkably higher than that of the non-VTE group (p < .05); the D-D level during the second trimester had the highest predictive value for VTE, with the optimal cutoff value of 1.40 mg/L, the sensitivity of 69.3%, and the specificity of 76.7%, and AUC = 0.73.

Conclusion: The D-D of pregnant women during pregnancy showed an increase trend with the gestational weeks, and they were all beyond the normal range. The D-D level in the second trimester has the highest predictive value for VTE.

Keywords: D- dimer; Pregnancy; plasma; pregnancy; venous thromboembolism.