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. 1978 May 4;509(1):188-93.
doi: 10.1016/0005-2736(78)90019-6.

Microviscosity changes during differentiation of neuroblastoma cells

S W de Laat, P T van der Saag, S A Nelemans, M Shinitzky

Microviscosity changes during differentiation of neuroblastoma cells

S W de Laat et al. Biochim Biophys Acta. .

Abstract

Microviscosity (eta) of the plasma-membrane lipid matrix was measured in exponentially growing and differentiating C1300 mouse neuroblastoma cells, attached to a glass substratum, by fluorescence polarisation of 1,6-diphenyl-1,3,5-hexatriene. Upon differentiation eta decreases progressively, reaching values below those observed in the growth phase. Treatment of the cells with dipalmitoyl phosphatidylcholine vesicles reversibly inhibits morphological differentiation. The results show that a high membrane fluidity is a prerequisite for differentiation.

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