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Review
. 2022 Jan;106(1):99-112.
doi: 10.1016/j.mcna.2021.08.011.

Tobacco Use Disorder

Frank T Leone  1 , Sarah Evers-Casey  2
Affiliations
Review

Tobacco Use Disorder

Frank T Leone et al. Med Clin North Am. 2022 Jan.

Abstract

Tobacco use disorder is highly prevalent; more than a billion individuals use tobacco worldwide. Popular views on the addictive potential of tobacco often underestimate the complex neural adaptations that underpin continued use. Although sometimes trivialized as a minor substance, effects of nicotine on behavior lead to profound morbidity over a lifetime of exposure. Innovations in processing have led to potent forms of tobacco and delivery devices. Proactive treatment strategies focus on pharmacotherapeutic interventions. Innovations on the horizon hold promise to help clinicians address this problem in a phenotypically tailored manner. Efforts are needed to prevent tobacco use for future generations.

Keywords: Nicotine; Pharmacotherapeutic interventions; Smoking treatment; Tobacco use.

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Conflict of interest statement

Conflict of Interest: Dr. Leone: None declared.

Ms. Evers-Casey: None declared.

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MeSH terms