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Comment
. 2022 Jan;18(1):3-4.
doi: 10.1038/s41582-021-00591-9.

Disease modification is not all - we need symptomatic therapies for Alzheimer disease

Jeffrey Cummings  1
Affiliations
Comment

Disease modification is not all - we need symptomatic therapies for Alzheimer disease

Jeffrey Cummings. Nat Rev Neurol. 2022 Jan.

Abstract

A new study found methylphenidate to be effective in treating apathy in individuals with Alzheimer disease. At a time when the recent aducanumab approval is focusing attention on the promise of disease-modifying therapies, the new findings highlight the importance of developing better symptomatic treatment options for individuals with psychiatric disorders of Alzheimer disease.

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References

    1. Vigen CL et al. Cognitive effects of atypical antipsychotic medications in patients with Alzheimer’s disease: outcomes from CATIE-AD. Am. J. Psychiatry 168, 831–839 (2011). - PMC - PubMed
    1. Cummings J, Lee G, Zhong K, Fonseca J. & Taghva K. Alzheimer’s disease drug development pipeline: 2021. Alzheimers Dement. (N.Y.) 7, e12179 (2021). - PMC - PubMed
    1. Mintzer J. et al. Effect of methylphenidate on apathy in patients with Alzheimer disease: the ADMET 2 randomized clinical trial. JAMA Neurol 10.1001/jamaneurol.2021.3356 (2021). - DOI - PMC - PubMed
    1. Marshall GA, Fairbanks LA, Tekin S, Vinters HV & Cummings JL Neuropathologic correlates of apathy in Alzheimer’s disease. Dement. Geriatr. Cogn. Disord. 21, 144–147 (2006). - PubMed
    1. Miller DS et al. Diagnostic criteria for apathy in neurocognitive disorders. Alzheimers Dement. (2021). - PMC - PubMed