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Comment
. 2021 Dec;53(12):1631-1633.
doi: 10.1038/s41588-021-00953-5. Epub 2021 Nov 25.

On powerful GWAS in admixed populations

Kangcheng Hou  1 , Arjun Bhattacharya  2 , Rachel Mester  3 , Kathryn S Burch  1 , Bogdan Pasaniuc  4   5   6   7
Affiliations
Comment

On powerful GWAS in admixed populations

Kangcheng Hou et al. Nat Genet. 2021 Dec.
No abstract available

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Conflict of interest statement

Competing interests

The authors declare no competing interests.

Figures

Fig. 1 |
Fig. 1 |
a, Comparison of the power of GWAS tests in admixed populations in simulations. ‘All’ represents distributions of power estimates from 50 simulation replicates and 3,000 causal SNPs uniformly drawn from the set of all SNPs, while ‘Differentiated’ distributions are restricted to the subset of SNPs (904 out of 3,000) with an absolute allele frequency difference >0.2 between Europeans and Africans (50 points per box plot). For box plots, the central lines correspond to the medians. The boxes represent the first and third quartiles of the points. The whiskers represent the minimum and maximum points located within 1.5× interquartile range from the first and third quartiles, respectively. In this study, we present results for an OR of 1.2; additional results, including null simulations, can be found in Supplementary Fig. 2. b, −log10(P) of SNP associations with LDL in the LDLR locus. The SNP with the strongest Tractor association P value has been framed and enlarged. Results at other considered GWAS regions for lipids (APOE, PCSK9, SORT1) showed similar patterns (Table 1).
See this image and copyright information in PMC

Comment in

  • Reply to: On powerful GWAS in admixed populations.
    Atkinson EG, Bloemendal A, Maihofer AX, Nievergelt CM, Daly MJ, Neale BM. Atkinson EG, et al. Nat Genet. 2021 Dec;53(12):1634-1635. doi: 10.1038/s41588-021-00975-z. Epub 2021 Nov 25. Nat Genet. 2021. PMID: 34824479 No abstract available.

Comment on

References

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