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Review
. 2022 Jan;14(1):e1768.
doi: 10.1002/wnan.1768. Epub 2021 Nov 25.

Designing nanoformulation for the nose-to-brain delivery in Parkinson's disease: Advancements and barrier

Pallavi Kiran  1 , Sujit Kumar Debnath  1 , Suditi Neekhra  1 , Vaishali Pawar  1 , Amreen Khan  1   2 , Faith Dias  1 , Shubham Pallod  1 , Rohit Srivastava  1
Affiliations
Review

Designing nanoformulation for the nose-to-brain delivery in Parkinson's disease: Advancements and barrier

Pallavi Kiran et al. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Jan.

Abstract

Parkinson's disease (PD), a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons, which results in the loss of motor activity. In the management of PD, the primary aim is to increase the dopamine content in the brain either by delivering the precursors of dopamine or by inhibiting the molecules responsible for dopamine degradation. Due to the low bioavailability, a higher dosage of drugs needs to be administered repeatedly for achieving the desired therapeutic effect. This repeated high dose not only increases the severe side effects but also produces tolerance in the body. Often, direct administration of drugs fails to ameliorate the symptoms as the unmodified drugs cannot cross the blood-brain barrier (BBB). Nanotherapeutic is at the forefront of the alternative treatment against the central nervous system (CNS) disorders due to the ability to circumvents the BBB. Here, all the available treatments for PD have been discussed with their limitation. The current trends of nanotherapeutics for PD have been explored. Suitability and formulation prospects for nasal delivery have been analyzed in detail to explore new research scope. The most effective approach is the nose-to-brain delivery for targeting drugs directly to the brain. This delivery bypasses the BBB and concentrates more drugs at the target site. Thus, developments of nose-to-brain delivery of nanoformulations explicit the new scope to manage PD better. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

Keywords: Parkinson's disease; blood-brain barrier; nanoformulation; nose-to-brain delivery; targeted delivery.

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References

REFERENCES

    1. Abbott, N. J. (2004). Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology. Neurochemistry International, 45, 545-552. https://doi.org/10.1016/j.neuint.2003.11.006
    1. Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010). Neurobiology of disease structure and function of the blood-brain barrier. Neurobiology of Disease, 37(1), 13-25. https://doi.org/10.1016/j.nbd.2009.07.030
    1. Agrawal, M., Ajazuddin, Tripathi, D. K., Saraf, S., Saraf, S., Antimisiaris, S. G., Mourtas, S., Hammarlund-Udenaes, M., & Alexander, A. (2017). Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease. Journal of Controlled Release, 260, 61-77. https://doi.org/10.1016/j.jconrel.2017.05.019
    1. Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018). Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs. Journal of Controlled Release, 281, 139-177. https://doi.org/10.1016/j.jconrel.2018.05.011
    1. Alexander, A., & Saraf, S. (2018). Nose-to-brain drug delivery approach: A key to easily accessing the brain for the treatment of Alzheimer's disease. Neural Regeneration Research, 13(12), 2102-2104. https://doi.org/10.4103/1673-5374.241458

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