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. 2022 Feb;40(2):467-473.
doi: 10.1007/s00345-021-03887-z. Epub 2021 Nov 26.

External validation of the Palacios' equation: a simple and accurate tool to estimate the new baseline renal function after renal cancer surgery

Alessandro Tafuri  1   2   3 , Marco Sandri  4 , Alberto Martini  5 , Umberto Capitanio  6 , Guglielmo Mantica  7 , Carlo Terrone  7 , Maria Furlan  8 , Claudio Simeone  8 , Daniele Amparore  9 , Francesco Porpiglia  9 , Andrea Minervini  10 , Andrea Mari  10 , Maria Angela Cerruto  1 , Alessandro Antonelli  11
Affiliations

External validation of the Palacios' equation: a simple and accurate tool to estimate the new baseline renal function after renal cancer surgery

Alessandro Tafuri et al. World J Urol. 2022 Feb.

Abstract

Purpose: To externally validate the Palacios' equation estimating the new baseline glomerular filtration rate (NB-GFR) after partial or radical-nephrectomy (PN, RN) for Renal cancer carcinoma (RCC).

Materials and methods: Our research group recently published two studies that investigated the association between renal function and cancer-specific survival in RCC. The first one included 3457 patients undergone RN or PN for a cT1-2 RCC coming from five high-volume centers; the second one considered 1767 patients undergone RN or PN for a cT1-4 RCC in a single high-volume center. From such datasets, available complete patients' data were used to calculate the predicted NB-GFR through the Palacios' equation: predicted NB-GFR = 35.03 + 0.65 ∙ preoperative GFR - 18.19 ∙ (if radical nephrectomy) - 0.25 ∙ age + 2.83 ∙ (if tumor size > 7 cm) - 2.09 ∙ (if diabetes). The observed NB-GFR was calculated by the CKD-EPI equation on serum creatinine at 3-12 months after surgery. Concordance between observed and predicted NB-GFR was evaluated by Lin's concordance correlation coefficient and Bland-Altman analysis.

Results: 2419 patients were included (1210, cohort #1; 1219, cohort #2). The median observed NB-GFR value in cohorts #1 and #2 was 73.0 ml/min/1.73 m2 (IQR 56.1-90.1) and 64.2 ml/min/1.73 m2 (IQR 49.6-83); the median predicted NB-GFR was 71.1 ml/min/1.73 m2 (IQR 58-81.5) and 62.6 ml/min/1.73m2 (IQR 47.9-75.9). The concordance line showed a slope of 0.80 and 0.86, and an intercept at 11.02 and 5.41 ml/min/1.73 m2 in the cohort#1 and #2, respectively. The Palacio's equation moderately over-estimated and under-estimated NB-GFR, for values below and above the cut-off of 50 ml/min/1.73 m2 and 35 ml/min/1.73m2 in cohort#1 and #2. The Lin's concordance correlation coefficient was 0.79 (95% CI 0.77-0.81) and 0.83 (95% CI 0.82-0.85).

Conclusions: We confirm the predictive performances of Palacios' equation, supporting its utilization in clinical practice.

Keywords: Glomerular filtration rate; Kidney neoplasms; Nephrectomy; New baseline renal function; Renal function decline.

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