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Review
. 2022 Mar;33(1):49-54.
doi: 10.1007/s00399-021-00830-y. Epub 2021 Nov 26.

Stereotactic radioablation for ventricular tachycardia

Stephan Hohmann  1 , Henrike A K Hillmann  1 , Johanna Müller-Leisse  1 , Jörg Eiringhaus  1 , Christos Zormpas  1 , Roland Merten  2 , Christian Veltmann  1 , David Duncker  3
Affiliations
Review

Stereotactic radioablation for ventricular tachycardia

Stephan Hohmann et al. Herzschrittmacherther Elektrophysiol. 2022 Mar.

Abstract
in English, German

Non-invasive stereotactic radioablation of ventricular tachycardia (VT) substrate has been proposed as a novel treatment modality for patients not eligible for catheter-based ablation or in whom this approach has failed. Initial clinical results are promising with good short-term efficacy in VT suppression and tolerable side effects. This article reviews the current clinical evidence for cardiac radioablation and gives an overview of important preclinical and translational results. Practical guidance is provided, and a cardiac radioablation planning and treatment workflow based on expert consensus and the authors' institutional experience is set out.

Die nichtinvasive stereotaktische Radioablation des Substrats ventrikulärer Tachykardien ist ein neuartiges Behandlungsverfahren für Patienten, die entweder für eine Katheterablation nicht infrage kommen oder bei denen interventionelle Ansätze nicht zum Erfolg geführt haben. Erste Ergebnisse klinischer Fallserien zeigen eine gute Wirksamkeit und tolerable unerwünschte Effekte im Kurzzeitverlauf. In dieser Arbeit stellen wir die aktuellen klinischen Daten zur kardialen Radioablation vor und geben eine Übersicht über wichtige Ergebnisse der Grundlagen- und translationalen Forschung in diesem Feld. Abschließend stellen wir basierend auf Expertenkonsensus und unseren Erfahrungen einen Workflow für die Planung und Durchführung der kardialen Bestrahlungstherapie in der Praxis vor.

Keywords: Cardiac radioablation; Catheter ablation; Multimodal imaging; Stereotactic ablative body radiation; VT.

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