COVID-19 as an infectome paradigm of autoimmunity

doi:10.1016/j.jaci.2021.11.009

Editorial

. 2022 Jan;149(1):63-64.

doi: 10.1016/j.jaci.2021.11.009. Epub 2021 Nov 24.

COVID-19 as an infectome paradigm of autoimmunity

Arad Dotan¹, Naim Mahroum², Dimitrios P Bogdanos³, Yehuda Shoenfeld⁴

Affiliations

¹ Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
² Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Medicine "B", Sheba Medical Center, Ramat Gan, Israel.
³ Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
⁴ Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Ariel University, Ari'el, Israel; Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University, Saint Petersburg, Russia. Electronic address: Yehuda.Shoenfeld@sheba.health.gov.il.

PMID: 34826507
PMCID: PMC8610602
DOI: 10.1016/j.jaci.2021.11.009

Editorial

COVID-19 as an infectome paradigm of autoimmunity

Arad Dotan et al. J Allergy Clin Immunol. 2022 Jan.

. 2022 Jan;149(1):63-64.

doi: 10.1016/j.jaci.2021.11.009. Epub 2021 Nov 24.

Authors

Arad Dotan¹, Naim Mahroum², Dimitrios P Bogdanos³, Yehuda Shoenfeld⁴

Affiliations

¹ Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
² Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Medicine "B", Sheba Medical Center, Ramat Gan, Israel.
³ Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
⁴ Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Ariel University, Ari'el, Israel; Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University, Saint Petersburg, Russia. Electronic address: Yehuda.Shoenfeld@sheba.health.gov.il.

PMID: 34826507
PMCID: PMC8610602
DOI: 10.1016/j.jaci.2021.11.009

No abstract available

Keywords: COVID-19; Microbiome; autoimmunity; infectome; lung microbiome.

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Figures

**Fig 1**
Mechanisms in which interaction of the novel SARS-CoV-2 and specific microbiome populations may increase autoimmunity: (1) Specific profiles of preexisting lung microbiota that enable excessive viral proliferation may increase the severity of illness and the rising chance of viral-induced autoimmunity. (2) COVID-19 might act as a final trigger leading to new onset of autoimmunity in individuals with an autoimmune-prone preexisting microbial composition, that is, an autoimmunity-prone microbiome “signature.” (3) Long-term implications of COVID-19 on the immune responses could initiate long-lasting transformational changes in microbial populations into microbiota, altering microbiota-self interactions and enhancing autoimmunity.

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Cited by

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Autoantibodies against SUMO1-DHX35 in long-COVID.
Thurner L, Fadle N, Regitz E, Preuss KD, Neumann F, Cetin O, Schormann C, Hoffmann MC, Herr C, Kheiroddin P, Rixecker TM, Bals R, Muller S, Thurner B, Kessel C, Kabesch M, Bewarder M, Heyne K, Lensch C, Kos IA. Thurner L, et al. J Transl Autoimmun. 2022 Nov 20;5:100171. doi: 10.1016/j.jtauto.2022.100171. eCollection 2022. J Transl Autoimmun. 2022. PMID: 36425003 Free PMC article.
The autonomic aspects of the post-COVID19 syndrome.
Dotan A, David P, Arnheim D, Shoenfeld Y. Dotan A, et al. Autoimmun Rev. 2022 May;21(5):103071. doi: 10.1016/j.autrev.2022.103071. Epub 2022 Feb 16. Autoimmun Rev. 2022. PMID: 35182777 Free PMC article. Review.
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Ruscitti P, Ursini F, Shoenfeld Y. Ruscitti P, et al. J Psychosom Res. 2023 Jun;169:111231. doi: 10.1016/j.jpsychores.2023.111231. Epub 2023 Mar 15. J Psychosom Res. 2023. PMID: 36959046 Free PMC article. No abstract available.
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Kavanagh KT, Cormier LE, Pontus C, Bergman A, Webley W. Kavanagh KT, et al. Medicine (Baltimore). 2024 Mar 22;103(12):e37502. doi: 10.1097/MD.0000000000037502. Medicine (Baltimore). 2024. PMID: 38518038 Free PMC article. Review.

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References

1. Berg G., Rybakova D., Fischer D., Cernava T., Vergès M.C., Charles T., et al. Microbiome definition re-visited: old concepts and new challenges. Microbiome. 2020;8:103. - PMC - PubMed
1. Li B., Selmi C., Tang R., Gershwin M.E., Ma X. The microbiome and autoimmunity: a paradigm from the gut–liver axis. Cell Mol Immunol. 2018;15:595–609. - PMC - PubMed
1. De Luca F., Shoenfeld Y. The microbiome in autoimmune diseases. Clin Exp Immunol. 2019;195:74–85. - PMC - PubMed
1. Dotan A., Muller S., Kanduc D., David P., Halpert G., Shoenfeld Y. The SARS-CoV-2 as an instrumental trigger of autoimmunity. Autoimmun Rev. 2021;20 - PMC - PubMed
1. Ferreira C., Viana S.D., Reis F. Is gut microbiota dysbiosis a predictor of increased susceptibility to poor outcome of COVID-19 patients? An update. Microorganisms. 2021;9:53. - PMC - PubMed

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[1] Berg G., Rybakova D., Fischer D., Cernava T., Vergès M.C., Charles T., et al. Microbiome definition re-visited: old concepts and new challenges. Microbiome. 2020;8:103. - PMC - PubMed

[2] Berg G., Rybakova D., Fischer D., Cernava T., Vergès M.C., Charles T., et al. Microbiome definition re-visited: old concepts and new challenges. Microbiome. 2020;8:103. - PMC - PubMed

[3] Li B., Selmi C., Tang R., Gershwin M.E., Ma X. The microbiome and autoimmunity: a paradigm from the gut–liver axis. Cell Mol Immunol. 2018;15:595–609. - PMC - PubMed

[4] Li B., Selmi C., Tang R., Gershwin M.E., Ma X. The microbiome and autoimmunity: a paradigm from the gut–liver axis. Cell Mol Immunol. 2018;15:595–609. - PMC - PubMed

[5] De Luca F., Shoenfeld Y. The microbiome in autoimmune diseases. Clin Exp Immunol. 2019;195:74–85. - PMC - PubMed

[6] De Luca F., Shoenfeld Y. The microbiome in autoimmune diseases. Clin Exp Immunol. 2019;195:74–85. - PMC - PubMed

[7] Dotan A., Muller S., Kanduc D., David P., Halpert G., Shoenfeld Y. The SARS-CoV-2 as an instrumental trigger of autoimmunity. Autoimmun Rev. 2021;20 - PMC - PubMed

[8] Dotan A., Muller S., Kanduc D., David P., Halpert G., Shoenfeld Y. The SARS-CoV-2 as an instrumental trigger of autoimmunity. Autoimmun Rev. 2021;20 - PMC - PubMed

[9] Ferreira C., Viana S.D., Reis F. Is gut microbiota dysbiosis a predictor of increased susceptibility to poor outcome of COVID-19 patients? An update. Microorganisms. 2021;9:53. - PMC - PubMed

[10] Ferreira C., Viana S.D., Reis F. Is gut microbiota dysbiosis a predictor of increased susceptibility to poor outcome of COVID-19 patients? An update. Microorganisms. 2021;9:53. - PMC - PubMed

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COVID-19 as an infectome paradigm of autoimmunity

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COVID-19 as an infectome paradigm of autoimmunity

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