Clinicopathological features and genomic profiles of hepatoid adenocarcinoma of the lung: Report of four cases

Abstract

Objective: Pathological features of hepatoid adenocarcinoma of the lung (HAL) are similar to those of hepatocellular carcinoma (HCC) and HAL has a poor prognosis. In this study, we aimed to elucidate clinicopathologic and molecular features of HAL.

Methods: Four cases of HAL patients with one lobe of the lung resected were enrolled into the study. Next generation sequencing (NGS) of a 425-gene panel was performed on tumor tissue samples.

Results: The most frequently mutated gene was TP53 in three cases of primary HAL and one case of metastatic HAL, with a mutation rate of 100%. Also, CDK8, CDKN2A, EPHA5, SMARCA4, and STK11 were detected as high-frequency mutations, with a mutation rate of 50%. The types of TP53 mutation included two missense variants and two frameshift ones. The TP53 mutation was related to the occurrence of HAL.

Conclusion: HAL could be caused by genetic mutations and is closely related to TP53 mutation.

Keywords: Hepatoid adenocarcinoma of the lung; Immunotherapy; NGS; PD1 and PD-L1; TP53 mutation.