Bioactive cytochalasans from the fungus Arthrinium arundinis DJ-13

Abstract

The investigation of the metabolites from Arthrinium arundinis DJ-13 grown in solid medium revealed six undescribed cytochalasans, arundisins A-F and twelve known compounds. Their structures were initially investigated in detail by spectroscopic analyses and were further confirmed by X-crystallography and ECD experiments. In the in vitro bioassays, arundisins A and B showed cytotoxic activity against the MCF-7 breast cancer cell line with IC₅₀ values of 18.82 ± 0.36 and 15.20 ± 0.42 μM, respectively. Arundisin F exhibited potent antibacterial activity against Escherichia coli with MIC of 8.00 μg/mL (kanamycin, 2.00 μg/mL), and arundisin D displayed gently antibacterial activity against Candida albicans with MIC of 32.00 μg/mL (Nystatin, 1.00 μg/mL).

Keywords: Antibacterial activity; Apiosporaceae; Arthrinium arundinis; Arundisin; Cytochalasan; Cytotoxicity.