Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder

Atiqul Haq Mazumder¹, Jennifer Barnett², Erkki Tapio Isometsä³, Nina Lindberg³, Minna Torniainen-Holm⁴, Markku Lähteenvuo^{5

6}, Kaisla Lahdensuo^{6

7}, Martta Kerkelä¹, Ari Ahola-Olli⁶, Jarmo Hietala^{8

9}, Olli Kampman^{10

11}, Tuula Kieseppä^{3

6

7}, Tuomas Jukuri^{1

6}, Katja Häkkinen^{5

6}, Erik Cederlöf⁴, Willehard Haaki^{6

8}, Risto Kajanne⁶, Asko Wegelius^{3

4

6}, Teemu Männynsalo^{6

12}, Jussi Niemi-Pynttäri^{6

12}, Kimmo Suokas^{6

10}, Jouko Lönnqvist^{4

13}, Jari Tiihonen^{5

14

15}, Tiina Paunio^{3

4

13}, Seppo Juhani Vainio^{16

17

18

19}, Aarno Palotie^{6

7

20

21}, Solja Niemelä^{8

9}, Jaana Suvisaari⁴, Juha Veijola^{1

22}

Affiliations

¹ Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland.
² Cambridge Cognition, University of Cambridge, Cambridge CB25 9TU, UK.
³ Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.
⁴ Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland.
⁵ Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland.
⁶ Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
⁷ Mehiläinen, Pohjoinen Hesperiankatu 17 C, 00260 Helsinki, Finland.
⁸ Department of Psychiatry, University of Turku, 20014 Turku, Finland.
⁹ Department of Psychiatry, Turku University Hospital, 20521 Turku, Finland.
¹⁰ Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
¹¹ Department of Psychiatry, Pirkanmaa Hospital District, 33521 Tampere, Finland.
¹² Social Services and Health Care Sector, City of Helsinki, 00099 Helsinki, Finland.
¹³ Department of Psychiatry, University of Helsinki, 00014 Helsinki, Finland.
¹⁴ Department of Clinical Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden.
¹⁵ Center for Psychiatry Research, Stockholm City Council, 11364 Stockholm, Sweden.
¹⁶ Infotech Oulu, University of Oulu, 90014 Oulu, Finland.
¹⁷ Northern Finland Biobank Borealis, Oulu University Hospital, 90220 Oulu, Finland.
¹⁸ Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland.
¹⁹ Kvantum Institute, University of Oulu, 90014 Oulu, Finland.
²⁰ Stanley Center for Psychiatric Research, The Broad Institute of MIT (Massachusetts Institute of Technology) and Harvard, Cambridge, MA 02142, USA.
²¹ Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
²² Department of Psychiatry, Oulu University Hospital, 90220 Oulu, Finland.

PMID: 34827421
PMCID: PMC8615595
DOI: 10.3390/brainsci11111422

Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder

Atiqul Haq Mazumder et al. Brain Sci. 2021.

. 2021 Oct 27;11(11):1422.

doi: 10.3390/brainsci11111422.

Authors

Affiliations

¹ Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland.
² Cambridge Cognition, University of Cambridge, Cambridge CB25 9TU, UK.
³ Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.
⁴ Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland.
⁵ Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland.
⁶ Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
⁷ Mehiläinen, Pohjoinen Hesperiankatu 17 C, 00260 Helsinki, Finland.
⁸ Department of Psychiatry, University of Turku, 20014 Turku, Finland.
⁹ Department of Psychiatry, Turku University Hospital, 20521 Turku, Finland.
¹⁰ Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
¹¹ Department of Psychiatry, Pirkanmaa Hospital District, 33521 Tampere, Finland.
¹² Social Services and Health Care Sector, City of Helsinki, 00099 Helsinki, Finland.
¹³ Department of Psychiatry, University of Helsinki, 00014 Helsinki, Finland.
¹⁴ Department of Clinical Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden.
¹⁵ Center for Psychiatry Research, Stockholm City Council, 11364 Stockholm, Sweden.
¹⁶ Infotech Oulu, University of Oulu, 90014 Oulu, Finland.
¹⁷ Northern Finland Biobank Borealis, Oulu University Hospital, 90220 Oulu, Finland.
¹⁸ Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland.
¹⁹ Kvantum Institute, University of Oulu, 90014 Oulu, Finland.
²⁰ Stanley Center for Psychiatric Research, The Broad Institute of MIT (Massachusetts Institute of Technology) and Harvard, Cambridge, MA 02142, USA.
²¹ Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
²² Department of Psychiatry, Oulu University Hospital, 90220 Oulu, Finland.

PMID: 34827421
PMCID: PMC8615595
DOI: 10.3390/brainsci11111422

Abstract

The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.

Keywords: PGS; bipolar disorder; cognition; hazardous drinking; reaction time; schizoaffective disorder; schizophrenia; visual memory.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Flowchart showing the selected study populations. SUPER, Suomalainen psykoosisairauksien perinnöllisyysmekanismien tutkimus; MHI-5, Mental Health Inventory-5; RT, Reaction Time; PAL, Paired Associative Learning.

See this image and copyright information in PMC

References

1. Sanchez-Roige S., Palmer A.A., Clarke T.K. Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse. Biol. Psychiatry. 2020;87:609–618. doi: 10.1016/j.biopsych.2019.09.011. - DOI - PMC - PubMed
1. Sanchez-Roige S., Palmer A.A., Fontanillas P., Elson S.L., Adams M.J., Howard D.M., Edenberg H.J., Davies G., Crist R.C., Deary I.J., et al. Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. Am. J. Psychiatry. 2019;176:107–118. doi: 10.1176/appi.ajp.2018.18040369. - DOI - PMC - PubMed
1. Meyers J.L., Chorlian D.B., Johnson E.C., Pandey A.K., Kamarajan C., Salvatore J.E., Aliev F., Subbie-Saenz de Viteri S., Zhang J., Chao M., et al. Association of Polygenic Liability for Alcohol Dependence and EEG Con-nectivity in Adolescence and Young Adulthood. Brain Sci. 2019;9:280. doi: 10.3390/brainsci9100280. - DOI - PMC - PubMed
1. Clarke T.K., Smith A.H., Gelernter J., Kranzler H.R., Farrer L.A., Hall L.S., Fernandez-Pujals A.M., MacIntyre D.J., Smith B.H., Hocking L.J., et al. Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. Addict. Biol. 2016;21:469–480. doi: 10.1111/adb.12245. - DOI - PMC - PubMed
1. Almeida O.P., Hankey G.J., Yeap B.B., Golledge J., Flicker L. Alcohol consumption and cognitive impairment in older men: A mendelian randomization study. Neurology. 2014;82:1038–1044. doi: 10.1212/WNL.0000000000000255. - DOI - PMC - PubMed

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Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder

Affiliations

Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Grants and funding

LinkOut - more resources

Full Text Sources