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. 2021 Nov 20;12(11):1832.
doi: 10.3390/genes12111832.

Measuring Exercise-Induced Secreted Protein Acidic and Rich in Cysteine Expression as a Molecular Tool to Optimize Personalized Medicine

Abdelaziz Ghanemi  1   2 , Mayumi Yoshioka  1 , Jonny St-Amand  1   2
Affiliations

Measuring Exercise-Induced Secreted Protein Acidic and Rich in Cysteine Expression as a Molecular Tool to Optimize Personalized Medicine

Abdelaziz Ghanemi et al. Genes (Basel). .

Abstract

The numerous exercise benefits for health as well as applications for diseases has lead to exercise being prescribed in many pathological conditions. Secreted protein acidic and rich in cysteine (SPARC) gene expression is stimulated by exercise and SPARC has been suggested as a molecular mediator of exercise. Therefore, we suggest using this property for personalized medicine. This can be achieved by prescribing the exercise with a pattern (duration, intensity, etc.) that corresponds to the optimum SPARC/Sparc expression. We expect this approach to optimize the exercise therapy in both the preventive and curative contexts. In the research field, measuring exercise -dependent expression of Sparc would represent a molecular tool to further optimize the selection of exercise animal models as well.

Keywords: exercise; expression; medicine; secreted protein acidic and rich in cysteine.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Measuring secreted protein acidic and rich in cysteine expression/concentration in biological samples following different patterns of exercise training would reflect the biological “responsiveness” to the physical activity and would predict the intensity of the benefits that exercise-induced changes will have. Such a property could be explored for instance to optimize the prescribed physical activity towards a personalized medicine approach and also select animal/cell models of exercise.
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