Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct 29;11(11):2013.
doi: 10.3390/diagnostics11112013.

Monitoring Approach of Fatality Risk Factors for Patients with Severe Acute Pancreatitis Admitted to the Intensive Care Unit. A Retrospective, Monocentric Study

Tudorel Mihoc  1 , Cristi Tarta  2 , Ciprian Duta  2 , Raluca Lupusoru  3   4 , Greta Dancu  3 , Monica Anca Oprescu-Macovei  5 , Amadeus Dobrescu  2 , Fulger Lazar  2
Affiliations

Monitoring Approach of Fatality Risk Factors for Patients with Severe Acute Pancreatitis Admitted to the Intensive Care Unit. A Retrospective, Monocentric Study

Tudorel Mihoc et al. Diagnostics (Basel). .

Abstract

Acute pancreatitis is an unpredictable disease affecting the pancreas and it is characterized by a wide range of symptoms and modified lab tests, thus there is a continuing struggle to classify this disease and to find risk factors associated with a worse outcome. The main objective of this study was to identify the risk factors associated with the fatal outcome of the intensive care unit's patients diagnosed and admitted for severe acute pancreatitis, the secondary objective was to investigate the prediction value for the death of different inflammatory markers at the time of their admission to the hospital. This retrospective study included all the patients with a diagnosis of acute pancreatitis admitted to the Intensive Care Unit of the Emergency County Hospital Timisoara between 1 January 2016 and 31 May 2021. The study included 53 patients diagnosed with severe acute pancreatitis, out of which 21 (39.6%) survived and 32 (60.4%) died. For the neutrophils/lymphocytes ratio, a cut-off value of 12.4 was found. When analyzing age, we found out that age above 52 years old can predict mortality, and for the platelets/lymphocytes ratio, a cut-off value of 127 was found. Combining the three factors we get a new model for predicting mortality, with an increased performance, AUROC = 0.95, p < 0.001. Multiple persistent organ failure, age over 50, higher values of C reactive protein, and surgery were risk factors for death in the patients with severe acute pancreatitis admitted to the intensive care unit. The model design from the neutrophils/lymphocytes ratio, platelets/lymphocytes ratio, and age proved to be the best in predicting mortality in severe acute pancreatitis.

Keywords: intensive care unit; neutrophils/lymphocytes ratio; platelets/lymphocytes ratio; severe acute pancreatitis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study population flow chart.
Figure 2
Figure 2
(A) Performance of PLR for predicting severe acute pancreatitis mortality according to ROC analysis; (B) performance of NLR for predicting severe acute pancreatitis mortality according to ROC analysis; (C) performance of AGE for predicting severe acute pancreatitis mortality according to ROC analysis. NLR—neutrophils-lymphocytes ratio; PLR—platelets-lymphocytes ratio; p—p-value.
Figure 3
Figure 3
Performance of the combination (NLR >12.4 + PLR >127 + AGE >52) for predicting severe acute pancreatitis mortality according to ROC analysis. NLR—neutrophils-lymphocytes ratio; PLR—platelets-lymphocytes ratio; p—p-value.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report.
    Öğütmen Koç D, Bengi G, Gül Ö, Özen Alahdab Y, Altıntaş E, Barutçu S, Bilgiç Y, Bostancı B, Cindoruk M, Çolakoğlu K, Duman D, Ekmen N, Eminler AT, Gökden Y, Günay S, Derviş Hakim G, Irak K, Kacar S, Kalkan İH, Kasap E, Köksal AŞ, Kuran S, Oruç N, Özdoğan O, Özşeker B, Parlak E, Saruç M, Şen İ, Şişman G, Tozlu M, Tunç N, Ünal NG, Ünal HÜ, Yaraş S, Yıldırım AE, Soytürk M, Oğuz D, Sezgin O. Öğütmen Koç D, et al. Turk J Gastroenterol. 2024 Nov 11;35(Suppl 1):S1-S44. doi: 10.5152/tjg.2024.24392. Turk J Gastroenterol. 2024. PMID: 39599919 Free PMC article. Review.

References

    1. Lankisch P.G., Apte M., Banks P.A. Acute pancreatitis. Lancet. 2015;386:85–96. doi: 10.1016/S0140-6736(14)60649-8. - DOI - PubMed
    1. Banks P.A., Bollen T.L., Dervenis C., Gooszen H.G., Johnson C.D., Sarr M.G., Tsiotos G.G., Vege S.S., Acute Pancreatitis Classification Working Group Classification of acute pancreatitis—2012: Revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62:102–111. doi: 10.1136/gutjnl-2012-302779. - DOI - PubMed
    1. Buter A., Imrie C.W., Carter C.R., Evans S., McKay C.J. Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis. Br. J. Surg. 2002;89:298–302. doi: 10.1046/j.0007-1323.2001.02025.x. - DOI - PubMed
    1. Dellinger E.P., Forsmark C.E., Layer P., Lévy P., Maraví-Poma E., Petrov M.S., Shimosegawa T., Siriwardena A.K., Uomo G., Whitcomb D.C., et al. Determinant-based classification of acute pancreatitis severity: An international multidisciplinary consultation. Ann Surg. 2012;256:875–880. doi: 10.1097/SLA.0b013e318256f778. - DOI - PubMed
    1. Isenmann R., Rau B., Beger H.G. Early severe acute pancreatitis: Characteristics of a new subgroup. Pancreas. 2001;22:274–278. doi: 10.1097/00006676-200104000-00008. - DOI - PubMed