doi: 10.1002/1097-0142(197805)41:5<1788::aid-cncr2820410521>3.0.co;2-d.
Demonstration of the prostatic origin of metastases: an immunohistochemical method for formalin-fixed embedded tissue
- PMID: 348296
- DOI: 10.1002/1097-0142(197805)41:5<1788::aid-cncr2820410521>3.0.co;2-d
Item in Clipboard
Demonstration of the prostatic origin of metastases: an immunohistochemical method for formalin-fixed embedded tissue
Cancer.
1978 May.
Abstract
An indirect immunohistochemical technique is described for identification of the prostatic origin of metastases in formalin fixed, paraffin or paraplast embedded material. A rabbit antiserum against the prostate specific acid phosphatase isoenzyme was developed. The method is applicable with or without previous decalcification. In 30 cases of prostatic carcinoma there was only one negative result, and in 20 cases of metastases from prostatic carcinoma positive results were obtained in every instance. All carcinomas (primary focus or metastasis) of non prostatic origin (55) stained negatively with the developed antiserum. The application and possible limitations of the method are discussed.
Similar articles
-
Comparative investigation of the mixed aggregation immunocytochemical technique and the indirect peroxidase technique for the detection of prostate specific acid phosphatase in paraffin or paraplast sections.Histochemistry. 1979 Jul;62(1):45-54. doi: 10.1007/BF00537005. Histochemistry. 1979. PMID: 383665
-
Prostatic origin of tumors. An immunohistochemical study.Am J Clin Pathol. 1980 Jun;73(6):735-9. doi: 10.1093/ajcp/73.6.735. Am J Clin Pathol. 1980. PMID: 6156593
-
The immunohistochemical detection of prostatic acid phosphatase: its possibilities and limitations in tumour histochemistry.Histochem J. 1981 Nov;13(6):961-73. doi: 10.1007/BF01002636. Histochem J. 1981. PMID: 6175605
-
Pathology of carcinoma of the prostate.Cancer. 1992 Jul 1;70(1 Suppl):235-53. doi: 10.1002/1097-0142(19920701)70:1+<235::aid-cncr2820701311>3.0.co;2-g. Cancer. 1992. PMID: 1376194 Review.
-
Enzyme patterns in cancer.Ann Clin Lab Sci. 1977 Mar-Apr;7(2):99-104. Ann Clin Lab Sci. 1977. PMID: 322572 Review.
Cited by
-
Comparative investigation of the mixed aggregation immunocytochemical technique and the indirect peroxidase technique for the detection of prostate specific acid phosphatase in paraffin or paraplast sections.Histochemistry. 1979 Jul;62(1):45-54. doi: 10.1007/BF00537005. Histochemistry. 1979. PMID: 383665
-
A novel hybridoma antibody (PASE/4LJ) to human prostatic acid phosphatase suitable for immunohistochemistry.Br J Cancer. 1989 Dec;60(6):887-92. doi: 10.1038/bjc.1989.385. Br J Cancer. 1989. PMID: 2605098 Free PMC article.
-
Expression of prostate-specific antigen in human prostate specimens in in vitro three-dimensional histoculture.In Vitro Cell Dev Biol Anim. 1993 Jul;29A(7):523-4. doi: 10.1007/BF02634143. In Vitro Cell Dev Biol Anim. 1993. PMID: 7689075 No abstract available.
-
Tumour marker immunoreactivity in adenocarcinoma.J Clin Pathol. 1988 Oct;41(10):1064-7. doi: 10.1136/jcp.41.10.1064. J Clin Pathol. 1988. PMID: 3192728 Free PMC article.
-
The role of immunocytochemistry in tumour pathology: a review.J R Soc Med. 1980 Sep;73(9):655-8. doi: 10.1177/014107688007300912. J R Soc Med. 1980. PMID: 7017134 Free PMC article. Review. No abstract available.