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Review
. 2021 Nov 9;22(22):12136.
doi: 10.3390/ijms222212136.

Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis

Ayush Kumar  1 , Madhav Bhatia  1
Affiliations
Review

Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis

Ayush Kumar et al. Int J Mol Sci. .

Abstract

Inflammation is a natural response to tissue injury. Uncontrolled inflammatory response leads to inflammatory disease. Acute pancreatitis is one of the main reasons for hospitalization amongst gastrointestinal disorders worldwide. It has been demonstrated that endogenous hydrogen sulfide (H2S), a gasotransmitter and substance P, a neuropeptide, are involved in the inflammatory process in acute pancreatitis. Cell adhesion molecules (CAM) are key players in inflammatory disease. Immunoglobulin (Ig) gene superfamily, selectins, and integrins are involved at different steps of leukocyte migration from blood to the site of injury. When the endothelial cells get activated, the CAMs are upregulated which leads to them interacting with leukocytes. This review summarizes our current understanding of the roles H2S, substance P and adhesion molecules play in acute pancreatitis.

Keywords: Hyaluronan; ICAM-1; MAdCAM-1; VAP-1; VCAM-1; acute pancreatitis; hydrogen sulfide; selectins; substance P.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
H2S synthesis via CSE.
Figure 2
Figure 2
H2S synthesis via CBS.
Figure 3
Figure 3
Layout of H2S synthesis via enzymatic and labile sources.
Figure 4
Figure 4
Interaction of H2S, substance P, and adhesion molecules in the regulation of inflammatory response in acute pancreatitis.
See this image and copyright information in PMC

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