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Review
. 2021 Nov 10;22(22):12154.
doi: 10.3390/ijms222212154.

The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review

Chiara Maddaloni  1 , Domenico Umberto De Rose  1 , Alessandra Santisi  1 , Ludovica Martini  1 , Stefano Caoci  1 , Iliana Bersani  1 , Maria Paola Ronchetti  1   2 , Cinzia Auriti  1
Affiliations
Review

The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review

Chiara Maddaloni et al. Int J Mol Sci. .

Abstract

Sepsis causes high rates of morbidity and mortality in NICUs. The estimated incidence varies between 5 and 170 per 1000 births, depending on the social context. In very low birth-weight neonates, the level of mortality increases with the duration of hospitalization, reaching 36% among infants aged 8-14 days and 52% among infants aged 15-28 days. Early diagnosis is the only tool to improve the poor prognosis of neonatal sepsis. Blood culture, the gold standard for diagnosis, is time-consuming and poorly sensitive. C-reactive protein and procalcitonin, currently used as sepsis biomarkers, are influenced by several maternal and fetal pro-inflammatory conditions in the perinatal age. Presepsin is the N-terminal fragment of soluble CD14 subtype (sCD14-ST): it is released in the bloodstream by monocytes and macrophages, in response to bacterial invasion. Presepsin seems to be a new, promising biomarker for the early diagnosis of sepsis in neonates as it is not modified by perinatal confounding inflammatory factors. The aim of the present review is to collect current knowledge about the role of presepsin in critically ill neonates.

Keywords: biomarkers; infants; neonate; point-of-care; sepsis; septic shock.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The mechanism of presepsin production.
See this image and copyright information in PMC

References

    1. Poggi C., Bianconi T., Gozzini E., Generoso M., Dani C. Presepsin for the detection of late-onset sepsis in preterm newborns. Pediatrics. 2015;135:68–75. doi: 10.1542/peds.2014-1755. - DOI - PubMed
    1. Shah B.A., Padbury J.F. Neonatal sepsis an old problem with new insights. Virulence. 2014;5:170–178. doi: 10.4161/viru.26906. - DOI - PMC - PubMed
    1. Ting J.Y., Synnes A., Roberts A., Deshpandey A., Dow K., Yoon E.W., Lee K.S., Dobson S., Lee S.K., Shah P.S., et al. Association between antibiotic use and neonatal mortality and morbidities in very low-birth-weight infants without culture-proven sepsis or necrotizing enterocolitis. JAMA Pediatr. 2016;170:1181–1187. doi: 10.1001/jamapediatrics.2016.2132. - DOI - PubMed
    1. Poggi C., Vasarri M.V., Boni L., Pugni L., Mosca F., Dani C. Reference ranges of Presepsin in preterm infants in the first 48 h of life: A multicenter observational study. Clin. Chim. Acta. 2020;508:191–196. doi: 10.1016/j.cca.2020.05.040. - DOI - PubMed
    1. Chiesa C., Natale F., Pascone R., Osborn J.F., Pacifico L., Bonci E., De Curtis M.C. Reactive protein and procalcitonin: Refe-rence intervals for preterm and term newborns during the early neonatal period. Clin. Chim. Acta. 2011;412:1053–1059. doi: 10.1016/j.cca.2011.02.020. - DOI - PubMed