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Review
. 2021 Nov 11;22(22):12215.
doi: 10.3390/ijms222212215.

Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Francisco Javier Manzano-Moreno  1   2 , Victor J Costela-Ruiz  2   3 , Enrique García-Recio  2   4 , Maria Victoria Olmedo-Gaya  5 , Concepción Ruiz  2   6   7 , Candelaria Reyes-Botella  1   2
Affiliations
Review

Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Francisco Javier Manzano-Moreno et al. Int J Mol Sci. .

Abstract

Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs.

Keywords: cytokines; diagnosis; microRNA; oral cancer; oral pathology; salivary biomarker.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Cristaldi M., Mauceri R., Di Fede O., Giuliana G., Campisi G., Panzarella V. Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives. Front. Physiol. 2019;10:1476. doi: 10.3389/fphys.2019.01476. - DOI - PMC - PubMed
    1. Guha N., Warnakulasuriya S., Vlaanderen J., Straif K. Betel quid chewing and the risk of oral and oropharyngeal cancers: A meta-analysis with implications for cancer control. Int. J. Cancer. 2014;135:1433–1443. doi: 10.1002/ijc.28643. - DOI - PubMed
    1. Jeng J.H., Chang M.C., Hahn L.J. Role of areca nut in betel quid-associated chemical carcinogenesis: Current awareness and future perspectives. Oral Oncol. 2001;37:477–492. doi: 10.1016/S1368-8375(01)00003-3. - DOI - PubMed
    1. Bellairs J.A., Hasina R., Agrawal N. Tumor DNA: An emerging biomarker in head and neck cancer. Cancer Metastasis Rev. 2017;36:515–523. doi: 10.1007/s10555-017-9685-x. - DOI - PMC - PubMed
    1. Woolgar J.A. Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma. Oral Oncol. 2006;42:229–239. doi: 10.1016/j.oraloncology.2005.05.008. - DOI - PubMed

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