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Review
. 2021 Nov 22;22(22):12571.
doi: 10.3390/ijms222212571.

Cervical Carcinoma: Oncobiology and Biomarkers

Larisa V Volkova  1 , Alexander I Pashov  2 , Nadezhda N Omelchuk  3
Affiliations
Review

Cervical Carcinoma: Oncobiology and Biomarkers

Larisa V Volkova et al. Int J Mol Sci. .

Abstract

Cervical cancer is one of the most common types of carcinomas causing morbidity and mortality in women in all countries of the world. At the moment, the oncology, oncobiology, and oncomorphology of cervical cancer are characterized by the accumulation of new information; various molecular biological, genetic, and immunohistochemical methods of investigation of the mechanisms of cervical carcinogenesis are tested and applied; targeted antitumour drugs and diagnostic, prognostic, and predictive biomarkers are being searched for. Many issues of the etiopathogenesis of cervical cancer have not been sufficiently studied, and the role of many biomarkers characterizing various stages of cervical carcinogenesis remains unclear. Therefore, the target of this review is to systematize and understand several problems in the pathogenesis of cervical cancer and to evaluate the significance and role of biomarkers in cervical carcinogenesis.

Keywords: biomarkers; carcinoma of the cervix; cervical carcinogenesis; immunohistochemistry.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Types of biomarkers for investigation of precancerous lesions and cervical carcinoma.
See this image and copyright information in PMC

References

    1. Female Genital Tumours . WHO Classification of Tumors. 5th ed. Volume 4 WHO Press; Geneva, Switzerland: 2020.
    1. World Health Organization. International Agency for Research on Cancer (IARC) Global Cancer Observatory (GCO) [(accessed on 15 May 2021)]. Available online: https://gco.iarc.fr.
    1. Ferlay J., Colombet M., Soerjomataram I., Parkin D.M., Piñeros M., Znaor A., Bray F. Cancer statistics for the year 2020: An overview. Int. J. Cancer. 2021;149:778–789. doi: 10.1002/ijc.33588. - DOI - PubMed
    1. Kaprin A.D., Starinskiy V.V., Shakhzadova A.O. The state of cancer care for the population of Russia in 2019. M.: MNIOI named after P.A. Herzen–Branch of the Federal State Budgetary Institution “National Medical Research Center of Radiology” of the Minzdrav of Russia. 2020. [(accessed on 15 May 2021)]. Available online: https://glavonco.ru/cancer_register/noMo^b.
    1. Comprehensive Cervical Cancer Control: A Guide to Essential Practice. 2nd ed. World Health Organization; Geneva, Switzerland: 2014. WHO Guidelines Approved by the Guidelines Review Committee. - PubMed

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