Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov 11;14(22):6806.
doi: 10.3390/ma14226806.

Design, Synthesis, and Preliminary Evaluation for Ti-Mo-Zr-Ta-Si Alloys for Potential Implant Applications

Madalina Simona Baltatu  1 , Mihaela Claudia Spataru  2 , Liliana Verestiuc  3 , Vera Balan  3 , Carmen Solcan  4 , Andrei Victor Sandu  1   5 , Victor Geanta  6 , Ionelia Voiculescu  7 , Petrica Vizureanu  1
Affiliations

Design, Synthesis, and Preliminary Evaluation for Ti-Mo-Zr-Ta-Si Alloys for Potential Implant Applications

Madalina Simona Baltatu et al. Materials (Basel). .

Abstract

Considering the future trends of biomaterials, current studies are focused on the corrosion resistance and the mechanical properties of new materials that need to be considered in the process of strengthening alloys with additive non-toxic elements. Many kinds of titanium alloys with different biocompatible elements (Mo, Si, Zr, etc.,) have been recently developed for their similar properties with human bone. Four new different alloys were obtained and investigated regarding their microstructure, mechanical, chemical, and biological behavior (in vitro and in vivo evaluation), the alloys are as follows: Ti15Mo7Zr15Ta, Ti15Mo7Zr15Ta0.5Si, Ti15Mo7Zr15Ta0.75Si, and Ti15Mo7Zr15Ta1Si. There were changes with the addition of the silicon element such as the hardness and the modulus of elasticity increased. An MTT assay confirmed the in vitro cytocompatibility of the prepared alloys.

Keywords: TiMoZrTaSi system; obtaining; osseointegration; titanium alloys.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Optical microscopy images (50× magnification): (a) Ti15Mo7Zr15Ta, (b) Ti15Mo7Zr15Ta0.5Si, (c) Ti15Mo7Zr15Ta0.75Si, (d) Ti15Mo7Zr15Ta1Si.
Figure 2
Figure 2
Diffractograms of experimental alloys: S1, Ti15Mo7Zr15Ta, S2, Ti15Mo7Zr15Ta0.5Si, S3, Ti15Mo7Zr15Ta0.75Si, S4, Ti15Mo7Zr15Ta1Si.
Figure 3
Figure 3
Micro-indentation graphic: (a) Ti15Mo7Zr15Ta, (b) Ti15Mo7Zr15Ta0.5Si, (c) Ti15Mo7Zr15Ta0.75Si, (d) Ti15Mo7Zr15Ta1Si.
Figure 4
Figure 4
Cell viability data after contact of the cells with Ti-Mo-Zr-Ta-Si metallic alloys (24 h, 48 h and 72 h).
Figure 5
Figure 5
Fluorescent microscopy (staining with calcein AM) for cells (Albino rabbit fibroblasts) at 72 h cell culture with Ti-Mo-Zr-Ta-Si materials (10× objective magnification).
Figure 6
Figure 6
Fluorescent microscopy (staining with calcein AM) for cells (MG63) at 72 h cell culture with Ti-Mo-Zr-Ta-Si materials (10× objective magnification).
Figure 7
Figure 7
X-Ray in control and experimental rabbits, 1, alloy; 2, implantory breach.
Figure 8
Figure 8
CT scan of the implanted area in control and experimental rabbits after 60 days.
Figure 9
Figure 9
Some aspects about the peri-implant areas in control and experimental rabbits, stain HE. First row of images: the periosteum nearby the implant, in control and implanted rabbits; the middle row of images: some aspects concerning osteogenesis of new bone between periosteum and alloys in control and implanted rabbits; the last row of images: the peri-implant aspects of the fibrous capsule structure and the new bone maturation in control and implanted rabbits.
Figure 10
Figure 10
Stain for OPN and MMP2 and MMP9 in control and experimental rabbits nearby the alloys. First row of images: stain IHC, positively cells for osteopontin (OPN); second row of images: stain ICH, positively cells for metalloproteinases 2 (MMP2); third row of images: stain ICH, positively cells for metalloproteinases 9 (MMP9).
See this image and copyright information in PMC

References

    1. Niinomi M. Mechanical properties of biomedical titanium alloys. Mater. Sci. Eng. A. 1998;243:231–236. doi: 10.1016/S0921-5093(97)00806-X. - DOI
    1. Niinomi M. Encyclopedia of Biomedical Engineering. Elsevier; Amsterdam, The Netherlands: 2019. Titanium Alloys; pp. 213–224. eBook.
    1. Chen Q., Thouas G.A. Metallic implant biomaterials. Mater. Sci. Eng. R Rep. 2015;87:1–57. doi: 10.1016/j.mser.2014.10.001. - DOI
    1. Bombac D.M., Brojan M., Fajfar P., Kosel F., Turk R. Review of materials in medical applications. RMZ Mater. Geoenvironment. 2007;54:471–499.
    1. Antoniac I., editor. Handbook of Bioceramics and Biocomposites. Springer; Berlin/Heidelberg, Germany: 2016. [(accessed on 10 September 2021)]. Available online: https://www.springer.com/gp/book/9783319124599.

LinkOut - more resources