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Review
. 2021 Nov 22;11(11):1279.
doi: 10.3390/life11111279.

HPV and Recurrent Respiratory Papillomatosis: A Brief Review

Amr Mohamed Ouda  1 , Ahmed Adel Elsabagh  1 , Ibrahim Mohamed Elmakaty  1 , Ishita Gupta  1   2 , Semir Vranic  1   2 , Hamda Al-Thawadi  1   2 , Ala-Eddin Al Moustafa  1   2   3
Affiliations
Review

HPV and Recurrent Respiratory Papillomatosis: A Brief Review

Amr Mohamed Ouda et al. Life (Basel). .

Abstract

Recurrent Respiratory Papillomatosis (RRP) is a rare but severe manifestation of human papillomavirus (HPV). As our knowledge about HPV infections has expanded, it has become possible to understand the course of RRP disease and unravel plausible efficient methods to manage the disease. However, the surge in reports on HPV has not been accompanied by a similar increase in research about RRP specifically. In this paper, we review the clinical manifestation and typical presentation of the illness. In addition, the pathogenesis and progression of the disease are described. On the other hand, we discuss the types of treatments currently available and future treatment strategies. The role of vaccination in both the prevention and treatment of RRP will also be reviewed. We believe this review is essential to update the general knowledge on RRP with the latest information available to date to enhance our understanding of RRP and its management.

Keywords: HPV; HPV infection; children; recurrent respiratory papillomatosis; vaccine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Outline of HPV type 6 and 11 infection pathways. Although RRP is not a malignancy, it can progress to cancer following further genomic deregulation caused by other oncogenes or oncoviruses.
See this image and copyright information in PMC

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