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Review
. 2021 Oct 23;57(11):1152.
doi: 10.3390/medicina57111152.

Solitary Fibrous Tumor of the Prostate: A Case Report and Literature Review

Yasumichi Takeuchi  1 , Daiki Kato  1 , Keita Nakane  1 , Kota Kawase  1 , Manabu Takai  1 , Koji Iinuma  1 , Chiemi Saigo  2 , Tatsuhiko Miyazaki  3 , Takuya Koie  1
Affiliations
Review

Solitary Fibrous Tumor of the Prostate: A Case Report and Literature Review

Yasumichi Takeuchi et al. Medicina (Kaunas). .

Abstract

Solitary fibrous tumors (SFTs) usually occur in the pleura and account for two-thirds of all cases; however, SFTs occurring in the prostate are extremely rare. Approximately 25 cases have been reported in the literature to date. This study reports the case of a 43-year-old man referred to our hospital with the chief complaint of a pelvic tumor after careful examination. The tumor marker levels were within normal limits. T2-weighted magnetic resonance imaging revealed a tumor, demonstrating primarily low signal intensity. It showed a capsule-like rim at the left lobe of the prostate, suggesting that the tumor was partially invading the rectal wall. Histopathological examination of needle-core biopsies showed spindle cell neoplasm with small and fusiform cells, strongly expressing signal transducer and activator of transcription 6 (STAT6) with a ramifying vascular network. Therefore, the clinical diagnosis of the patient was SFT of the prostate and robot-assisted radical prostatectomy was performed. Histopathological examination revealed that the tumor was composed of spindle cells with patternless and staghorn patterns. Immunohistochemical analysis showed a strong expression of STAT6. Furthermore, the tumor was partially positive for CD34. Therefore, the patient was diagnosed with SFT of the prostate. Two years after the initial diagnosis, the patient was alive with normal erectile function, continence status, and no evidence of the disease.

Keywords: case report; prostatic tumor; rare case; solitary fibrous tumor.

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Conflict of interest statement

The authors declare that they have no competing interest.

Figures

Figure 1
Figure 1
T2-weighted magnetic resonance image demonstrating the tumor mainly with low signal intensity (arrow). The tumor shows a capsule-like rim at the left lobe of the prostate, suggesting that it is partially invading the rectal wall (arrow).
Figure 2
Figure 2
Robot-assisted radical prostatectomy findings. A firm adhesion between the tumor and the rectal wall is observed (arrow).
Figure 3
Figure 3
Macroscopic examination reveals a solid tumor measuring 3 × 3.4 cm on the left lobe of the resected prostate.
Figure 4
Figure 4
Histopathological examination revealing a well-circumscribed mass composed of spindle cells arranged without any particular architecture (A) and associated with variable amounts of collagen and a distinctive vascularization (B).
Figure 5
Figure 5
Immunohistochemical analysis of tumor cells showing strong expression of the signal transducer and active tor of transcription 6 (A). The tumor cells are partially positive for CD34 (B).
See this image and copyright information in PMC

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