Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Nov 5;57(11):1209.
doi: 10.3390/medicina57111209.

Peptide-Based Drug Delivery Systems

Dmitriy Berillo  1 , Adilkhan Yeskendir  2 , Zharylkasyn Zharkinbekov  2 , Kamila Raziyeva  2 , Arman Saparov  2
Affiliations
Review

Peptide-Based Drug Delivery Systems

Dmitriy Berillo et al. Medicina (Kaunas). .

Abstract

Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied by intravenous administration, however they are of artificial nature and thus may induce side effects and possess lack of ability to penetrate the blood-brain barrier. An analysis of nontoxic drug delivery systems and an establishment of prospective trends in the development of drug delivery systems was needed. This review paper summarizes data, mainly from the past 5 years, devoted to the use of peptide-based carriers for delivery of various toxic drugs, mostly anticancer or drugs with limiting bioavailability. Peptide-based drug delivery platforms are utilized as peptide-drug conjugates, injectable biodegradable particles and depots for delivering small molecule pharmaceutical substances (500 Da) and therapeutic proteins. Controlled drug delivery systems that can effectively deliver anticancer and peptide-based drugs leading to accelerated recovery without significant side effects are discussed. Moreover, cell penetrating peptides and their molecular mechanisms as targeting peptides, as well as stimuli responsive (enzyme-responsive and pH-responsive) peptides and peptide-based self-assembly scaffolds are also reviewed.

Keywords: cell penetrating peptides; drug carriers; drug delivery system; peptide-based; scaffolds; stimuli responsive; targeted delivery.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Peptide-based drug delivery systems.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Varanko A., Saha S., Chilkoti A. Recent trends in protein and peptide-based biomaterials for advanced drug delivery. Adv. Drug Deliv. Rev. 2020;156:133–187. doi: 10.1016/j.addr.2020.08.008. - DOI - PMC - PubMed
    1. Prasad V., McCabe C., Mailankody S. Low-value approvals and high prices might incentivize ineffective drug development. Nat. Rev. Clin. Oncol. 2018;15:399–400. doi: 10.1038/s41571-018-0030-2. - DOI - PubMed
    1. Elsharkasy O.M., Nordin J.Z., Hagey D.W., de Jong O.G., Schiffelers R.M., Andaloussi S.E., Vader P. Extracellular vesicles as drug delivery systems: Why and how? Adv. Drug Deliv. Rev. 2020;159:332–343. doi: 10.1016/j.addr.2020.04.004. - DOI - PubMed
    1. Hossen S., Hossain M.K., Basher M.K., Mia M.N.H., Rahman M.T., Uddin M.J. Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review. J. Adv. Res. 2019;15:1–18. doi: 10.1016/j.jare.2018.06.005. - DOI - PMC - PubMed
    1. Bukhovets A.V., Fotaki N., Khutoryanskiy V.V., Moustafine R.I. Interpolymer Complexes of Eudragit® Copolymers as Novel Carriers for Colon-Specific Drug Delivery. Polymers. 2020;12:1459. doi: 10.3390/polym12071459. - DOI - PMC - PubMed