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. 2021 Nov 13;26(22):6861.
doi: 10.3390/molecules26226861.

Briarane-Related Diterpenoids from Octocoral Briareum stechei

Thanh-Hao Huynh  1   2 , Choo-Aun Neoh  3 , Yu-Chi Tsai  2 , Zhi-Kang Yao  1   4 , Li-Guo Zheng  2 , Pin-Chang Huang  2 , Zhi-Hong Wen  1   5 , Jih-Jung Chen  6 , Yu-Jen Wu  7 , Ping-Jyun Sung  1   2   8   9   10
Affiliations

Briarane-Related Diterpenoids from Octocoral Briareum stechei

Thanh-Hao Huynh et al. Molecules. .

Abstract

A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1-4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.

Keywords: Briareum stechei; briaexcavatolie; briarane; briastecholide; iNOS.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of briaexcavatolide P (1), briastecholides B (2) and C (3), and briarenol R (4).
Figure 2
Figure 2
(a) Key COSY (formula image), HMBC (formula image), and (b) stereoview of 2 and calculated distances (Å) between selected protons with key NOESY (formula image) correlations.
Figure 3
Figure 3
(a) Key COSY (formula image), HMBC (formula image), and (b) stereoview of 3 and calculated distances (Å) between selected protons with key NOESY (formula image) correlations.
Figure 4
Figure 4
Western blotting showed that briaexcavatolide P (1) reduced the expression of iNOS. Data were normalized to the cells treated with LPS only, and cells treated dexamethasone (Dex.) were used as positive control. Data are expressed as the mean ± SEM (n = 3). * Significantly different from cells treated with LPS (p < 0.05).
See this image and copyright information in PMC

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