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Review
. 2021 Nov 19;10(11):2508.
doi: 10.3390/plants10112508.

A Review of Rhazya stricta Decne Phytochemistry, Bioactivities, Pharmacological Activities, Toxicity, and Folkloric Medicinal Uses

Abdulaziz Albeshri  1 , Nabih A Baeshen  1 , Thamer A Bouback  1   2 , Abdullah A Aljaddawi  1
Affiliations
Review

A Review of Rhazya stricta Decne Phytochemistry, Bioactivities, Pharmacological Activities, Toxicity, and Folkloric Medicinal Uses

Abdulaziz Albeshri et al. Plants (Basel). .

Abstract

The local medicinal plant Rhazya stricta Decne is reviewed for its folkloric medicinal, phytochemical, pharmacological, biological, and toxicological features. R. stricta has been used widely in different cultures for various medical disorders. The phytochemical studies performed on the R. stricta extract revealed many alkaloidal and fatty acid compounds. Moreover, several flavonoid and terpenoid compounds were also detected. Pharmacological activates of R. stricta extracts are approved to possess antimicrobial, antioxidant, anticancer, antidiabetic, and antihypertensive activities. Additionally, R. stricta extract was found to hold biological activates such as larvicidal and phytoremediation activates R. stricta extract was found to be toxic, genotoxic, and mutagenic. R. stricta contains novel phytochemical compounds that have not been investigated pharmacologically. Further research is needed through in vitro and in vivo experiments to pave the road for these compounds for medical, veterinary, and ecological uses.

Keywords: Rhazya stricta; alkaloid; folkloric medicine; pharmacological activity; phytochemicals; toxicity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Map shows the regional distribution of the R. stricta plant [7].
Figure 2
Figure 2
Photos captured of (A) whole plant of R. stricta or its parts (B) fruits, (C) flowers, and (D) stem and leaves from Wadi Fatimah, Makkah.
Figure 3
Figure 3
Chemical structures of some alkaloidal compounds (a) Rhazidigenine, (b) Rhazimanine, (c) Rhazimine, (d) Rhazine, (e) Rhazicine, and (f) Rhazimal named after the R. stricta plant [29].
See this image and copyright information in PMC

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