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. 2021 Nov 13;13(11):2271.
doi: 10.3390/v13112271.

ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection

Johanna Tietäväinen  1   2 , Outi Laine  1   2 , Satu Mäkelä  1   2 , Heini Huhtala  3 , Ilkka Pörsti  1   2 , Antti Vaheri  4 , Jukka Mustonen  1   2
Affiliations

ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection

Johanna Tietäväinen et al. Viruses. .

Abstract

Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982-2017. Patients' blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area (n = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection.

Keywords: ABO blood groups; AKI; Puumala hantavirus; blood pressure; capillary leakage; rhesus blood groups.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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