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Review
. 2021 Nov 5;13(11):3951.
doi: 10.3390/nu13113951.

l-Arginine and COVID-19: An Update

Ayobami Adebayo  1 , Fahimeh Varzideh  1   2 , Scott Wilson  1 , Jessica Gambardella  1   2 , Michael Eacobacci  1 , Stanislovas S Jankauskas  1   2 , Kwame Donkor  1 , Urna Kansakar  1   2 , Valentina Trimarco  3 , Pasquale Mone  1 , Angela Lombardi  1 , Gaetano Santulli  1   2   4
Affiliations
Review

l-Arginine and COVID-19: An Update

Ayobami Adebayo et al. Nutrients. .

Abstract

l-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.

Keywords: COVID-19; ROS; SARS-CoV-2; T cells; antiviral therapies; arginine; coronavirus; cytokine storm; endothelium; immune response; immunity; inflammation; nitric oxide; nitrosylation; oxidative stress; viral infections.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Positive and negative effects of nitric oxide (NO).
Figure 2
Figure 2
Main effects of l-Arginine on the immune system.
See this image and copyright information in PMC

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