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Clinical Trial
. 2021 Nov 9;13(11):3988.
doi: 10.3390/nu13113988.

Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention

Ciniselli Chiara Maura  1 , Bruno Eleonora  2 , Oliverio Andreina  2 , Baldassari Ivan  2 , Pastori Marta  1 , Signoroni Stefano  3 , Vitellaro Marco  3 , Ricci Maria Teresa  3 , Milione Massimo  4 , Cattaneo Laura  4 , Gariboldi Manuela  5 , Mancini Andrea  6 , Rivoltini Licia  7 , Morelli Daniele  8 , Pasanisi Patrizia  2 , Verderio Paolo  1
Affiliations
Clinical Trial

Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention

Ciniselli Chiara Maura et al. Nutrients. .

Abstract

Background: A total colectomy and a frequent life-long endoscopic surveillance are guaranteed to patients with Familial Adenomatous Polyposis (FAP) to reduce their risk of duodenal and rectal stump cancers. However, after surgery, individuals with FAP suffer from an increased number of diarrheal discharges that force them to dietary restrictions. A non-randomized pilot study was conducted to assess whether a three-month low-inflammatory Mediterranean dietary intervention reduces gastro-intestinal markers of inflammation in FAP individuals. The aim of the present work is to evaluate the participant's adherence to the proposed dietary recommendations and the change in their number of diarrheal discharges.

Methods: 26 FAP individuals aged >18 years, who underwent a total colectomy with ileo-rectal anastomosis and were involved in the surveillance program at the Fondazione IRCCS Istituto Nazionale Tumori of Milan, were included in the present analysis.

Results: FAP individuals significantly reduced the Not recommended foods (p-value: 0.002) and increased the consumption of the Recommended ones (p-value: 0.075). The adherence to the proposed dietary recommendations was accompanied by a significant decrease in the number of diarrheal discharges (p-value: 0.008).

Conclusions: This study suggests that adhering to a low-inflammatory Mediterranean diet has a potential protective effect on the number of diarrheal discharges in FAP individuals.

Keywords: FAP individuals; Mediterranean low-inflammatory diet; diarrheal discharges; dietary adherence; dietary questionnaires.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Distribution of food intake of Recommended, Not Recommended and Neutral at T0 (upper part) and T1 (bottom part). On the x-axis are reported the dietary items considered and on the y-axis the number of subjects according to the absolute frequency of intake.
Figure 2
Figure 2
Scores modulation. The box plots report the overall distribution of Recommended (A), Not Recommended (B) and Neutral scores (C) at T0 and T1. Each box indicates the 25th and 75th centiles. The horizontal line inside the box indicates the median; the black diamond represents the mean; the whiskers indicate the range measure.
Figure 3
Figure 3
Diarrheal discharges modulation. The box plots report the overall distribution of diarrheal discharges at T0 and T1. Each box indicates the 25th and 75th centiles. The horizontal line inside the box indicates the median; the black diamond represents the mean; the whiskers indicate the range measure.
Figure 4
Figure 4
MEDAS modulation. On the x-axis are reported the dietary items considered and on the y-axis the number of subjects according to the absolute frequency of Recommended (A) and Not Recommended (B) intake.
Figure 5
Figure 5
Heatmap FAP-patient level. Representation of the MEDAS questionnaire data of the 26 considered patients together with the number of diarrheal discharges and fecal calprotectin.
See this image and copyright information in PMC

References

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