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Clinical Trial
. 2021 Nov 17;13(11):4112.
doi: 10.3390/nu13114112.

Effectiveness of Crohn's Disease Exclusion Diet for Induction of Remission in Crohn's Disease Adult Patients

Martyna Szczubełek  1 , Karolina Pomorska  1 , Monika Korólczyk-Kowalczyk  1 , Konrad Lewandowski  1 , Magdalena Kaniewska  1 , Grażyna Rydzewska  1   2
Affiliations
Clinical Trial

Effectiveness of Crohn's Disease Exclusion Diet for Induction of Remission in Crohn's Disease Adult Patients

Martyna Szczubełek et al. Nutrients. .

Abstract

Exclusive enteral nutrition (EEN) is a first-line treatment in active, mild to moderate Crohn's disease (CD) in children. The Crohn's disease exclusion diet (CDED), which avoids products known to have a pro-inflammatory effect on the intestinal mucosa, presents similar effectiveness to EEN for inducing remission in the paediatric population. The aim of the study was to evaluate the effectiveness of the CDED in inducing remission in adult patients. Between March 2020 and May 2021, 32 patients in a gastroenterology outpatient centre were treated according to the assumptions of the CDED. The patients were seen at baseline, at week 6, and at week 12 of the study. During the visits, anthropometric measurements and laboratory tests were performed, Crohn's disease activity index (CDAI) was calculated, and the Inflammatory Bowel Disease Questionnaire (IBDQ) was completed. The study included a total of 32 participants, 18 women (56.3%) and 14 men (43.7%). Clinical remission was obtained in 76.7% patients after 6 weeks and in 82.1% after 12 weeks of therapy. Calprotectin levels were significantly lower in the second follow-up compared with baseline (p = 0.021). The CDED is an effective therapy for inducing remission in the adult CD population.

Keywords: Crohn’s disease; Crohn’s disease exclusion diet; dietary therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Clinical remission (CDAI < 150) in patients after 6 (a) and after 12 (b) weeks of CDED.
Figure 2
Figure 2
Clinical response (reduction in CDAI > 100 points) in patients after 6 (a) and after 12 (b) weeks of CDED.
Figure 3
Figure 3
Analysis of changes in follow-up measurements regarding: (a) CDAI level; (b) calprotectin level; (c) CRP level; (d) WBC level; (e) IBDQ level.
Figure 3
Figure 3
Analysis of changes in follow-up measurements regarding: (a) CDAI level; (b) calprotectin level; (c) CRP level; (d) WBC level; (e) IBDQ level.
Figure 4
Figure 4
Severity of CD in patients at baseline, 1st follow-up, and 2nd follow-up. Horizontal lines represent 95% confidence intervals (CI).
See this image and copyright information in PMC

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