Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan-Feb;97(1):118-121.
doi: 10.1016/j.abd.2021.09.003. Epub 2021 Nov 10.

Leukocytoclastic vasculitis after exposure to COVID-19 vaccine

Matheus Fritzen  1 , Gabriella Di Giunta Funchal  2 , Mariana Oliveira Luiz  3 , Giovanna Steffenello Durigon  4
Affiliations

Leukocytoclastic vasculitis after exposure to COVID-19 vaccine

Matheus Fritzen et al. An Bras Dermatol. 2022 Jan-Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Purpuric lesions on the lower limbs on the first day of hospitalization.
Figure 2
Figure 2
Multiple petechiae and palpable purpura.
Figure 3
Figure 3
(A and B), Histopathology of the skin showing diffuse inflammatory infiltrate in the dermis (Hematoxylin & eosin, ×100). (C), Postcapillary dermal vessels permeated by neutrophils with leukocytoclasia. Presence of signs of endothelial damage with mural and interstitial fibrin deposits, in addition to extravasated red blood cells. (Hematoxylin & eosin, ×400). (D), Direct immunofluorescence showing granular deposits of IgA and IgM on the postcapillary vessel wall.
See this image and copyright information in PMC

References

    1. Cohen S.R., Prussick L., Kahn J.S., Gao D.X., Radfar A., Rosmarin D. Leukocytoclastic vasculitis flare following the COVID-19 vaccine. Int J Dermatol. 2021:1032–1033. - PMC - PubMed
    1. Jariwala S., Vernon N., Shliozberg J. Henoch-Schönlein purpura after hepatitis A vaccination. Ann Allergy Asthma Immunol. 2011;107:180–181. - PubMed
    1. Bonetto C., Trotta F., Felicetti P., Alarcón G.S., Santuccio C., Bachtiar N.S., et al. Vasculitis as an adverse event following immunization – Systematic literature review. Vaccine. 2016;34:6641–6651. - PubMed
    1. Bostan E., Gulseren D., Gokoz O. New-onset leukocytoclastic vasculitis after COVID-19 vaccine. Int J Dermatol. 2021;60:1305–1306. - PMC - PubMed
    1. Vojdani A., Vojdani E., Kharrazian D. Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins with Tissue Antigens: Implications for Autoimmune Diseases. Front in Immunol. 2021;11:1–16. - PMC - PubMed

Substances

Supplementary concepts