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Comment
. 2022 Jan;38(1):7-8.
doi: 10.1016/j.pt.2021.11.002. Epub 2021 Nov 24.

The Batman and Robin of liver-stage immunity to malaria

William R Heath  1 , Lauren E Holz  2 , Daniel Fernandez-Ruiz  2
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Comment

The Batman and Robin of liver-stage immunity to malaria

William R Heath et al. Trends Parasitol. 2022 Jan.

Abstract

Malaria parasites replicate within the liver shortly after infection. This stage can be controlled by CD8 T cells, but which subsets undertake this function is unclear. Lefebvre et al. now elegantly show that effector memory T (TEM) cells are avid participants, working as a dynamic duo with liver tissue-resident memory T (TRM) cells to combat infection.

Keywords: CD8 T cells; liver; malaria; memory; vaccines.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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